Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock
To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock.
Hypothesis: Hepatic perfusion did not improved after EGDT in patients with septic shock.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock|
- ICG-PDR and R15 before treatment, after EGDT and 24 hours after EGDT. [ Time Frame: 30 hours ] [ Designated as safety issue: Yes ]
- 28 days mortality [ Time Frame: 28 days ] [ Designated as safety issue: Yes ]Follow up to determine the mortality in 28 days after inclusion
|Study Start Date:||December 2012|
|Estimated Study Completion Date:||February 2014|
|Estimated Primary Completion Date:||February 2014 (Final data collection date for primary outcome measure)|
Objective To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock.
Methods A prospective observational study was carried out. The eligible patients were treated with the standard procedure of EGDT. The hemodynamic data were recorded. Oxygen metabolism and hepatic function were monitored. Indocyanine clearance test was applied to detect the hepatic perfusion. Hemodynamics, hepatic perfusion, oxygen metabolism and hepatic function were compared before treatment, after EGDT and 24 hours after EGDT.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02060773
|Contact: Xiaohua Qiu, MDfirstname.lastname@example.org|
|Affiliated Zhongda Hospital of Southeast University||Recruiting|
|Nanjing, Jiangsu, China, 210009|
|Contact: Xiaohua Qiu, MD 0086-025-83262553 email@example.com|
|Principal Investigator: Xiwen Zhang, MD|
|Sub-Investigator: Xiaohua Qiu, MD|