Computational Tools for Early Diagnosis of Memory Disorders (ProsKuopio)
The Virtual Physiological Human: DementiA Research Enabled by IT (VPH-DARE@IT) is a four-year IT-project funded through the European Union (EU). The project consortium involves a total of 21 universities and industrial partners from 10 European countries. The project delivers the first patient-specific predictive models for early differential diagnosis of dementia and their evolution. An integrated clinical decision support platform will be validated / tested by access to a dozen databases of international cross-sectional and longitudinal studies. As a part of the VPH-DARE@IT project, a new prospective cohort will be collected in Kuopio. This prospective cohort will be used to test further the modeling approaches and tools developed by using the retrospective databases.
Mild Cognitive Impairment
|Study Type:||Observational [Patient Registry]|
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Target Follow-Up Duration:||18 Months|
|Official Title:||Virtual Physiological Human (VPH) Dementia Research Enabled by IT - Prospective Cohort Kuopio|
- Sensitivity, specificity and accuracy of models for diagnosis of memory disorders [ Time Frame: during a single visit, i.e., day 1 and for one study group (MCI) after 18 month follow-up ] [ Designated as safety issue: No ]The models developed the VPH-DARE project will be tested in this prospective cohort. Sensitivity, specificity and accuracy of the model will be tested in differential diagnosis between the study groups as well as the accuracy of prediction cognitive decline as measured by neuropsychological test battery in the MCI group.
Biospecimen Retention: Samples With DNA
whole blood, serum, plasma, white cells
|Study Start Date:||December 2013|
|Estimated Study Completion Date:||June 2016|
|Estimated Primary Completion Date:||June 2016 (Final data collection date for primary outcome measure)|
Patients with mild Alzheimer's disease
Patients with vascular dementia
Patients with fronto-temporal dementia
Mild cognitive impairment
Patients with mild cognitive impairment
The Virtual Physiological Human: DementiA Research Enabled by IT (VPH-DARE@IT) is a four-year IT-project funded through the European Union (EU). The project will develop multiscale models of the ageing brain in order to account simultaneously for the patient-specific biochemical, metabolic and biomechanical brain substrate, as well as for genetic, clinical, demographic and lifestyle determinants. An integrated clinical decision support platform will be validated and tested by access to a dozen databases of international cross-sectional and longitudinal studies.
Modeling approaches developed by using the retrospective databases will be tested using a new prospective cohort that will be collected in Kuopio as a part of the VPH-DARE@IT project. The study population at university of Eastern Finland (UEF) will be a total of 120 subjects: 20 healthy controls (HC), 20 mild to moderate Alzheimer's disease (AD) patients, 20 vascular dementia (VAD) patients, 20 fronto-temporal dementia (FTD) patients and 40 subjects with mild cognitive impairment (MCI). This study is referred as VPH-DARE@IT Prospective study in Kuopio or "ProsKuopio".
Please refer to this study by its ClinicalTrials.gov identifier: NCT02050464
|Department of Neurology and Brain Research Unit, Institute of Clinical Medicine, University of Eastern Finland|
|Kuopio, Finland, FI-70211|
|Kuopio University Hospital|
|Kuopio, Finland, FI-70211|
|VTT Technical Research Centre of Finland|
|Principal Investigator:||Hilkka Soininen, Professor||University of Eastern Finland|