Calcium Ionophore Solution Can Increase Fertilization Rate in Patients During Intracytoplasmic Sperm Injection(ICSI) Who Have Poor Ovarian Reserve?
The aim of this study is to evaluate calcium ionophore solution on fertilization rate of patients during intracytoplasmic sperm injection who have poor ovarian reserve
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
|Official Title:||Effect of Calcium Ionophore Solution on Fertilization Rate During ICSI Cycles of Poor Ovarian Reserve Patients|
- calcium ionophore solution effect on fertilization rate [ Time Frame: 18 hours ] [ Designated as safety issue: No ]Before Intracytoplasmic sperm injection adding calcium ionophore solution to the medium can increase fertilization rate of oocytes or not?
- Calcium ionophore solution increase on going pregnancy rate [ Time Frame: up to 21 weeks ] [ Designated as safety issue: No ]İf the calcium ionophore can increase fertilization rate , pregnancy rate up to 20 weeks, can increase or not?
- calcium ionophore can decrease fertilization rate [ Time Frame: 18 hours ] [ Designated as safety issue: No ]To detect if calcium ionophore can affect fertilization rate in a reverse manner than expected
|Study Start Date:||January 2014|
|Estimated Study Completion Date:||August 2014|
|Estimated Primary Completion Date:||April 2014 (Final data collection date for primary outcome measure)|
No Intervention: control group
the patients who have no intervention with calcium ionophore during ICSI cycle
Experimental: calcium ionophore
the patients whose oocytes are incubated with calcium ionophore solution during ICSI cycle
Other: calcium ionophore solution
After microinjection of sperm into the oocyte, oocytes are incubated for 15 minutes in a 30 microlitre droplet of calcium ionomycin solution
During ICSI cycle , female patients who have poor ovarian reserve have low oocyte numbers. So by calcium ionophore solution which we know that it can increase fertilization rate in males who have azospermia or globozoospermia. we planned to check if this solution can increase fertilization rate also in poor ovarian reserve patients?
Please refer to this study by its ClinicalTrials.gov identifier: NCT02045914
|Contact: Pinar Caglar Aytac, MDfirstname.lastname@example.org|
|baskent university obstetric and gynecology, reproductive endocrinology and IVF unit||Recruiting|
|Adana, Kisla, Turkey, 01230|
|Principal Investigator: pinar caglar aytac|
|Study Director:||esra bulgan kilicdag, prof md||Baskent University|
|Study Chair:||Huriye Ayse Parlakgumus, md||Baskent University|
|Principal Investigator:||Pinar Caglar Aytac, md||Baskent University|
|Study Chair:||Cok Tayfun, md||Baskent University|
|Study Chair:||Bulent Haydardedeoglu, assoc Prof||Baskent University|
|Study Chair:||Erhan Simsek, md||Baskent University|