Adductor Canal Versus Femoral Nerve Block for Analgesia Post Total Knee Arthroscopy

This study is currently recruiting participants.
Verified January 2014 by Changi General Hospital
Sponsor:
Information provided by (Responsible Party):
Changi General Hospital
ClinicalTrials.gov Identifier:
NCT02033603
First received: January 9, 2014
Last updated: January 12, 2014
Last verified: January 2014
  Purpose

Total knee arthroplasty or replacement (TKA) is a surgery performed for osteoarthritis of the knee which is increasingly performed as the population ages. It is a painful surgery and one of the methods to reduce post-operative pain is performing a regional anaesthesia technique. The current practice is to perform a femoral nerve block (FNB) which blocks the nerves supplying the knee joint and the thigh muscles (quadriceps). This provides effective analgesia. However, it also results in weakness of the quadriceps and may result in falls post-operatively.

Adductor canal block (ACB) is a new, alternative regional anaesthesia technique which is hypothesised to provide as effective analgesia, with less quadriceps weakness compared to FNB, hence potentially reducing the risk of falls post-operatively.

Investigators aim to study if the analgesia provided by ACB is as good as FNB while preserving quadriceps strength.


Condition Intervention
Total Knee Arthroplasty
Total Knee Replacement
Femoral Nerve Block
Adductor Canal Block
Procedure: Femoral Nerve Block. Adductor Canal Block
Drug: Ropivacaine

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Femoral Nerve Block for Analgesia Post Total Knee Arthroplasty

Resource links provided by NLM:


Further study details as provided by Changi General Hospital:

Primary Outcome Measures:
  • Morphine consumption [ Time Frame: first 24 hours ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Pain scores [ Time Frame: 1, 6, 12, 24, 48 ] [ Designated as safety issue: No ]
  • Morphine consumption [ Time Frame: 48 hours ] [ Designated as safety issue: No ]
  • Side effects of opioids- sedation, nausea and vomiting [ Time Frame: 48 hours ] [ Designated as safety issue: Yes ]
  • Quadriceps strength, ability to mobilise [ Time Frame: 24, 48 hours ] [ Designated as safety issue: No ]

Estimated Enrollment: 30
Study Start Date: January 2014
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Femoral Nerve Block
Femoral Nerve block performed with 0.5% Ropivacaine 30mls (150mg)
Procedure: Femoral Nerve Block. Adductor Canal Block
Regional Anaesthesia - Femoral Nerve Block or Adductor Canal block performed with 0.5% Ropivacaine 30mls (150mg)
Drug: Ropivacaine
Active Comparator: Adductor Canal block
Adductor Canal block performed with 0.5% Ropivacaine 30mls (150mg)
Procedure: Femoral Nerve Block. Adductor Canal Block
Regional Anaesthesia - Femoral Nerve Block or Adductor Canal block performed with 0.5% Ropivacaine 30mls (150mg)
Drug: Ropivacaine

  Eligibility

Ages Eligible for Study:   45 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ages 45-85
  • American Society of Anaesthesiologists physical status 1-3
  • BMI 18-35 kg/m2

Exclusion Criteria:

  • inability to give consent, communicate, cooperate
  • Patients with regular consumption of strong opioids (morphine, oxycodone) or steroids
  • Patients with allergy to local anaesthetics or any drugs included in the study
  • Patients with lower limb surgery in the preceding year
  • Patients with pre-existing neurological deficits
  • Patients who are unsuitable for general anaesthetics (eg difficult airway)
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT02033603

Locations
Singapore
Changi General Hospital Recruiting
Singapore, Singapore, 529889
Contact: CTRU    67888833      
Sponsors and Collaborators
Changi General Hospital
  More Information

No publications provided

Responsible Party: Changi General Hospital
ClinicalTrials.gov Identifier: NCT02033603     History of Changes
Other Study ID Numbers: 2013/ 921/ D
Study First Received: January 9, 2014
Last Updated: January 12, 2014
Health Authority: Singapore: Institutional Review Board

Keywords provided by Changi General Hospital:
Total knee arthroplasty
Total knee replacement
Femoral Nerve Block
Adductor Canal Block

Additional relevant MeSH terms:
Ropivacaine
Anesthetics, Local
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
Sensory System Agents
Peripheral Nervous System Agents
Central Nervous System Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on April 17, 2014