Motor Learning in Stroke

This study is currently recruiting participants.
Verified December 2013 by Department of Veterans Affairs
Sponsor:
Information provided by (Responsible Party):
Department of Veterans Affairs
ClinicalTrials.gov Identifier:
NCT02017574
First received: December 16, 2013
Last updated: NA
Last verified: December 2013
History: No changes posted
  Purpose

Stroke is one of the leading causes of chronic disability in veterans. Stroke is associated with significant loss of mobility, increased risk of falling, cardiovascular disease, depression and neuro-cognitive impairment. These deficits negatively impact the independent completion of the Activities of Daily Living (ADLs). Task-oriented training has emerged as the dominant therapeutic intervention in the rehabilitation of chronic stroke victims. The effectiveness of these interventions may be enhanced through facilitation of implicit knowledge rather than explicit knowledge. Specifically, implicit learning increases retention and improves transfer of the improved motor function outside of the lab environment. Moreover, implicit motor control reduces the burden imposed on cognitive resources as the skill is performed automatically (i.e. do not have to 'think' about it). The amount and type of feedback individuals receive while learning a new task (or relearning in the case of rehabilitation) has been shown to influence the type of learning (i.e. implicit or explicit). Thus the purpose of the current study is to determine the effect of different types of feedback during motor learning on the learning type and the resultant impact on functional outcomes (i.e. motor performance, retention, and cognitive workload) in chronic stroke patients.


Condition Intervention Phase
Cerebral Stroke
Behavioral: Reaching Task
Phase 0

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: Facilitating Implicit Learning to Improve Neurorehabilitation in Stroke

Resource links provided by NLM:


Further study details as provided by Department of Veterans Affairs:

Primary Outcome Measures:
  • Motor Performance [ Time Frame: 2 Years ] [ Designated as safety issue: No ]
    Quality of motor behavior


Secondary Outcome Measures:
  • EEG derived event related potential [ Time Frame: 2 Years ] [ Designated as safety issue: No ]
    Brain electrophsyiology measure of attentional processes


Estimated Enrollment: 30
Study Start Date: October 2013
Estimated Study Completion Date: September 2015
Estimated Primary Completion Date: September 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Implicit Group
Receives little feedback about task performance during learning
Behavioral: Reaching Task
Learn a reaching task that requires coordination of the arm segments
Active Comparator: Control
Receives detailed feedback about task performance during learning
Behavioral: Reaching Task
Learn a reaching task that requires coordination of the arm segments

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   45 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Subcortical ischemic stroke greater than 3 months prior.
  • Between 45 and 80 years of age.
  • Residual hemiparetic upper extremity deficits.
  • Adequate language and neurocognitive function to participate in training (MMSE, CESD, aphasia screening).
  • Right hand dominant.
  • Upper Extremity Fugl-Meyer score of 25 or greater.

Exclusion Criteria:

  • History of cortical stroke.
  • No mobility of less affected arm.
  • Failure to meet the RRDC assessment clinic criteria for medical eligibility.
  • MMSE score less than 27.
  • CES-D score greater than 16.
  • Unable to pass a hearing test (i.e. must be able to hear sounds of 45 dB or less).
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT02017574

Contacts
Contact: Jeremy C Rietschel, PhD MA BA (410) 605-7000 ext 3233 jeremy.rietschel@va.gov
Contact: Ronald N Goodman, PhD (410) 605-7000 ronald.goodman@va.gov

Locations
United States, Maryland
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD Recruiting
Baltimore, Maryland, United States, 21201
Contact: Kara Longo, MS    410-605-7000 ext 4804    klongo@grecc.umaryland.edu   
Principal Investigator: Jeremy C Rietschel, PhD MA BA         
Sponsors and Collaborators
Investigators
Principal Investigator: Jeremy C Rietschel, PhD MA BA Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
  More Information

No publications provided

Responsible Party: Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT02017574     History of Changes
Other Study ID Numbers: N0970-M
Study First Received: December 16, 2013
Last Updated: December 16, 2013
Health Authority: United States: Federal Government

Keywords provided by Department of Veterans Affairs:
Stroke
Cerebral Infarction

Additional relevant MeSH terms:
Stroke
Cerebral Infarction
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Brain Infarction
Brain Ischemia

ClinicalTrials.gov processed this record on April 21, 2014