Attentional Bias and Attentional Bias Modification Treatment in Obsessive-compulsive Disorder

This study is currently recruiting participants. (see Contacts and Locations)
Verified December 2013 by University of Sao Paulo
Sponsor:
Information provided by (Responsible Party):
Roseli Shavitt, University of Sao Paulo
ClinicalTrials.gov Identifier:
NCT02014194
First received: November 25, 2013
Last updated: December 17, 2013
Last verified: December 2013
  Purpose

Obsessive-compulsive disorder is a chronic condition. Even with proper treatment, no significant improvement is reached in about 30% to 40% of patients. Thus, the development of new treatment strategies is necessary. The attentional bias - ability to aversive stimuli in capturing the attention of an individual compared to a neutral stimulus - has been extensively studied. Already training attentional bias modification has been shown effective in reducing anxiety present in other anxiety disorders.This project aims to: 1 - generate knowledge on attentional bias in individuals with OCD through the use of a standardized protocol developed for OCD; 2 - available to the scientific community the first specific paradigm for the study of attentional bias in OCD patients, 3 - test the effectiveness of a training protocol for reversing attentional bias in individuals with OCD.


Condition Intervention
Obsessive-compulsive Disorder
Behavioral: attentional bias modification treatment

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Attentional Bias and Attentional Bias Modification Treatment in Obsessive-compulsive Disorder

Resource links provided by NLM:


Further study details as provided by University of Sao Paulo:

Primary Outcome Measures:
  • Percentage of reduction of attentional bias [ Time Frame: Patients will be followed an expected average of 7 weeks (baseline, 2 sessions per week - totalizing 5 weeks, 10 sessions and a session after end of treatment). Measures of attentional bias will be assessed in baseline, session 5 and after session 10. ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Reduction of anxiety symptoms [ Time Frame: Baseline, session 5 and end of treatment (after session 10) (expected average of 7 weeks) ] [ Designated as safety issue: No ]

Estimated Enrollment: 30
Study Start Date: November 2013
Estimated Primary Completion Date: July 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: attentional bias modification, 2 arms
Measure of attentional bias modification treatment after 10 sessions of attentional bias modification (two arms). There are two arms with 15 OCD patients each one.
Behavioral: attentional bias modification treatment
The attentional bias modification treatment is a behavioral computerized program (software e-prime)

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria: - 30 patients with obsessive-compulsive diagnosis according to DSM-V

  • 30 health controls

Exclusion Criteria: - doing any kind of behavioral therapy in the moment

-

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT02014194

Locations
Brazil
University of Sao Paulo Medical School Recruiting
Sao Paulo, Brazil, 05403010
Contact: Maria Alice Mathis, Phd    55 11 26616972    alicedemathis@gmail.com   
Sponsors and Collaborators
Roseli Shavitt
  More Information

No publications provided

Responsible Party: Roseli Shavitt, MD, Phd, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT02014194     History of Changes
Other Study ID Numbers: 13674113.2.0000.0068
Study First Received: November 25, 2013
Last Updated: December 17, 2013
Health Authority: Brazil: National Committee of Ethics in Research

Keywords provided by University of Sao Paulo:
Attentional Bias
Attentional Bias modification treatment

Additional relevant MeSH terms:
Disease
Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Pathologic Processes
Personality Disorders
Mental Disorders
Anxiety Disorders

ClinicalTrials.gov processed this record on October 01, 2014