The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory

This study is currently recruiting participants.
Verified December 2013 by Taipei Veterans General Hospital, Taiwan
Sponsor:
Information provided by (Responsible Party):
vghtpe user, Taipei Veterans General Hospital, Taiwan
ClinicalTrials.gov Identifier:
NCT02006615
First received: December 5, 2013
Last updated: NA
Last verified: December 2013
History: No changes posted
  Purpose

We hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.


Condition Intervention
Central Nervous System Diseases
Device: rTMS

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory in Stroke, Parkinson, and Elderly Patients

Resource links provided by NLM:


Further study details as provided by Taipei Veterans General Hospital, Taiwan:

Primary Outcome Measures:
  • Repeatable Battery for the Assessment of Neuropsychological Status [ Time Frame: up to 3 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Reaction time [ Time Frame: up to 3 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 150
Study Start Date: July 2013
Estimated Study Completion Date: July 2015
Estimated Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 5Hz rTMS
rTMS group
Device: rTMS
5Hz rTMS over M1 and inferior frontal lobe
Other Name: Magstim rapid2
Sham Comparator: Sham rTMS
Sham stimulation
Device: rTMS
5Hz rTMS over M1 and inferior frontal lobe
Other Name: Magstim rapid2

Detailed Description:

Excitatory (>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal gyrus.

  Eligibility

Ages Eligible for Study:   30 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Ischemic or hemorrhagic cerebrovascular lesion, Parkinsonism disease, elderly people

Exclusion Criteria:

  • Seizure, metalic implantation, other contra-indications for TMS; Dementia or severe cognitive impairment
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT02006615

Contacts
Contact: Po-Yi Tsai, MD 886-228757293 vivitsai0518@gmail.com
Contact: Chih-Jou Lai, MD 886-228757361 milly1204@gmail.com

Locations
Taiwan
Taipei Veterans General Hospital Recruiting
Taipei, Taiwan, 11217
Contact: Po-Yi Tsai, MD    886-228757293    vivitsai0518@gmail.com   
Sponsors and Collaborators
Taipei Veterans General Hospital, Taiwan
Investigators
Principal Investigator: Po-Yi Tsai, MD Taipei Veterans General Hospital, Taiwan
  More Information

Additional Information:
No publications provided

Responsible Party: vghtpe user, MD, Taipei Veterans General Hospital, Taiwan
ClinicalTrials.gov Identifier: NCT02006615     History of Changes
Other Study ID Numbers: 2013-07-011A
Study First Received: December 5, 2013
Last Updated: December 5, 2013
Health Authority: Taiwan : Food and Drug Administration

Additional relevant MeSH terms:
Central Nervous System Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on April 16, 2014