Hiperemezis and Serotonin Elevated Serum Serotonin Levels in Hyperemesis
Serotonin excretion was investigated in the nausea and vomiting associated with hiperemezis gravid arum.
Markedly Reduced Food Intake
|Study Design:||Observational Model: Case-Only
Time Perspective: Cross-Sectional
|Official Title:||Relationship Between Elevated Serum Serotonin Levels in Symptomatic Patients With Hyperemezis|
- serum serotonin levels in hiperemezis gravidarum [ Time Frame: 6-14week pregnancy ] [ Designated as safety issue: No ]
- ıs there any assosiation between serotonin levels and severity of symptoms in pregnant women with hiperemezis [ Time Frame: 6-14week pregnancy ] [ Designated as safety issue: No ]
- ıs there any assosiation between other serum parameters includes estrogen,progesterone and serum beta hcg [ Time Frame: 6-14week pregnancy ] [ Designated as safety issue: No ]
|Study Start Date:||October 2013|
|Estimated Study Completion Date:||March 2014|
|Estimated Primary Completion Date:||February 2014 (Final data collection date for primary outcome measure)|
The occurrence of severe nausea and vomiting of early pregnancy (hiperemezis gravid arum) is estimated between 0.3% to 1% of all pregnancies. Although hiperemezis gravid arum has been recognized for a long time, its pathophysiologic mechanisms are still poorly understood. Many theories have been advocated, but to date none of these have been convincing.
It has been demonstrated that the nausea and vomiting associated with increased in serotonin liberation. This has provided a rationale for the treatment of these symptoms with specific serotonin antagonists.
The aim of this trial was to investigate the possible relationship between hiperemezis gravid arum and serotonin liberation.
|Contact: hediye dağdeviren, email@example.com|
|Bakirkoy Dr Sadi Konuk Training and Research Hospital||Recruiting|
|Istanbul, Turkey, 34140|
|Contact: hediye dagdeviren, md 5079872463 firstname.lastname@example.org|
|Principal Investigator: huseyin cengiz, md|
|Study Chair:||hüseyin cengiz, md||bakirkoy dr sadi konuk training and research hospital|