Trial record 5 of 75 for:    Ataxias and Cerebellar or Spinocerebellar Degeneration

The Effect of Whole Body Vibration Training on Neuromuscular Property in Individuals With Ataxia

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Ya-Ju Chang, Chang Gung University
ClinicalTrials.gov Identifier:
NCT01983631
First received: November 7, 2013
Last updated: November 13, 2013
Last verified: November 2013
  Purpose

The Cerebellum contains ten percent of the total volume of the brain and receives brain, spinal cord and vestibular sensory input. The organization of vestibular and somato-sensory afferent informations are also reported to be impaired in patients with cerebellum dysfunctions. Ataxia and impaired balance control are common symptoms in individuals with spinocerebellar ataxia (SCA). Previous studies have shown that patient with cerebellar damage are usually agonist and antagonist muscle coordination problem. Past studies also found the regulation of reciprocal Ia inhibition was impaired in patients with spinaocerebellar ataxia. In chronic phase, weakness might be developed due to deconditioned. All deficits mentioned above might lead to a decrease functional ability. Therefore, increasing somato-sensory and vestibular input, normalizing the modulation of recriprocal inhibition, and improve muscle strength might be able to improve the functional abilities of individuals with SCA.

Recently, whole body vibration (WBV) has been trained for health groups. Studies showed that WBV training were able to improve muscle strength, balance control, and functional ability. However, there is no evidence showed that whether the whole body vibration training can affect the brain and spinal cord for the regulation of neural circuits. Whether also can affect for maximal voluntary contraction and improve central fatigue. No previous studies that whole body vibration training for SCA.

Therefore, the purpose of this research was to investigate the intracortical facilitation and inhibition, reciprocal Ia inhibition, low frequency depression, maximal voluntary contraction, interpolated twitch technique to compare the different between the SCA and health subject. Also to investigate the short term and long term effect of WBV.


Condition Intervention
Spinocerebellar Ataxia
Other: Whole body vibration training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Chang Gung University:

Primary Outcome Measures:
  • Muscle twitch force [ Time Frame: Baseline, 4 weeks. ] [ Designated as safety issue: No ]
    Measure of changes in muscle twitch force by interpolation twitch technique

  • Muscle voluntary activity level [ Time Frame: Baseline, 4 weeks ] [ Designated as safety issue: No ]
    Measure of changes in muscle voluntary activity level by interpolation twitch technique.

  • Balance [ Time Frame: Baseline, 4 weeks ] [ Designated as safety issue: No ]
    Measure of changes in berge balance scale and one-leg standing.

  • Severity of cerebellar ataxia [ Time Frame: Baseline, 4 weeks ] [ Designated as safety issue: No ]
    Measure of changes in international cooperative ataxia rating scale(ICARS).


Enrollment: 17
Study Start Date: April 2011
Study Completion Date: March 2013
Primary Completion Date: March 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: WBV group
Stage 1: Short-term Whole body vibration(3 minutes in half-squatting position)
Other: Whole body vibration training
No Intervention: Non-WBV group
Stage 1 : Controlled group
Experimental: training group
Stage 2: Long-term WBV training (3 sessions per week for 4 weeks)
Other: Whole body vibration training
No Intervention: non-training group
Stage 2: Controlled group

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical diagnosis of spinocerebellar ataxia
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01983631

Locations
Taiwan
Chang Gung University
Taoyuan, Taiwan, 333
Sponsors and Collaborators
Chang Gung University
  More Information

No publications provided

Responsible Party: Ya-Ju Chang, Associate Professor, Chang Gung University
ClinicalTrials.gov Identifier: NCT01983631     History of Changes
Other Study ID Numbers: 100-1184B
Study First Received: November 7, 2013
Last Updated: November 13, 2013
Health Authority: Taiwan: Department of Health

Keywords provided by Chang Gung University:
Whole body vibration
Reciprocal inhibition
Spinocerebellar ataxia
voluntary activation level

Additional relevant MeSH terms:
Ataxia
Spinocerebellar Ataxias
Spinocerebellar Degenerations
Cerebellar Ataxia
Cerebellar Diseases
Dyskinesias
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Brain Diseases
Central Nervous System Diseases
Spinal Cord Diseases
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Genetic Diseases, Inborn

ClinicalTrials.gov processed this record on October 01, 2014