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Spicy Diet on Salty Taste and Salt Intake

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Zhiming Zhu, Third Military Medical University
ClinicalTrials.gov Identifier:
NCT01982669
First received: October 27, 2013
Last updated: December 15, 2013
Last verified: December 2013
  Purpose

Excess dietary salt intake is closely associated with the development of hypertension and cardiocerebral vascular diseases. Reduction in high salt intake significantly prevents hypertension and cardiocerebral events. Currently, few promising method is available to reduce salt intake in human. This study focus on examining the salty taste in population-level and exploring whether dietary factors can reduce salt intake through acting on salty taste.


Condition Intervention Phase
Salty Taste
Spicy Diet
Other: No Intervention
Phase 4

Study Type: Observational
Study Design: Observational Model: Ecologic or Community
Time Perspective: Cross-Sectional
Official Title: Effects of Spicy Diet on Salty Taste and Salt Intake

Resource links provided by NLM:


Further study details as provided by Third Military Medical University:

Primary Outcome Measures:
  • Effects of spicy diet on salt taste [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
    Daily spicy food intake was evaluated by diet questionnaire and salty taste was tested through salt perception and super-threshold examination on the first day when the participant was investigated.


Secondary Outcome Measures:
  • Effects of spicy diet on salt intake [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
    Daily spicy food intake was evaluated by diet questionnaire on the first day when the participant was investigated and then 24-hour urine was collected during the following day and salt intake was assessed by 24-hour urinary sodium excretion.

  • Effects of spicy diet on obesity parameters. [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
    Daily spicy food intake was evaluated by diet questionnaire and body mass index and waist circumference were measured on the first day when the participant was investigated.

  • Effects of spicy diet on blood pressure [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
    Daily spicy food intake was evaluated by diet questionnaire and systolic and diastolic blood pressure were measured on the first day when the participant was investigated.


Biospecimen Retention:   Samples With DNA

Blood, Urine


Enrollment: 606
Study Start Date: February 2013
Study Completion Date: December 2013
Primary Completion Date: November 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Different degree of spicy food intake Other: No Intervention

Detailed Description:

Hypertension and its related complications are common health problems that can lead to multiple organ damage and death. Excessive salt intake plays very important role in the development of hypertension. Reducing salt intake prevents high blood pressure as well as cardiocerebral vascular diseases.

The experimental design is a multi-center, random-order, double-blind observational study to investigate the salty taste and salt intake in population-level.

A total of 600 individuals from four cities in China are recruited in this study. This study aims to explore the salty taste characterization and salt intake in participants who like or dislike spicy diet through questionnaire, spicy preference, salty perception and super-threshold as well as the 24-hour urinary sodium excretion.

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Residents from four cities(Shenyang, Jinan, Chengdu and Chongqing) in China

Criteria

Inclusion Criteria:

  • Age ≥ 18 years and ≤ 55 years.
  • Willing and able to provide written informed consent.
  • Willing and able to comply with all study procedures.

Exclusion Criteria:

  • Type 1 diabetes.
  • Secondary hypertension, hypertension emergency.
  • Hypogeusia or loss due to neural system disease or oral and digestive disease.
  • Capsaicin allergy and poor compliance.
  • Recently oral diuretics and participate in other pharmacological experiment in 3 months.
  • Acute infection, cancer, serious arrhythmias, drug or alcohol abuse.
  • Currently have cold, fever, acidosis, dehydration, diarrhea, vomiting during the study.
  • Unwilling or unable to communication due to the dysnoesia and language disorders
  • Severe neural or psychiatric diseases that would preclude fully understand and corporation in the study.
  • Pregnancy or lactation
  • Unwilling to sign the informed consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01982669

Locations
China, Chongqing
Daping Hospital, The Third Military Medical University
Chongqing, Chongqing, China, 400042
Sponsors and Collaborators
Zhiming Zhu