Hemodialysis Frequency and the Calcification Propensity of Serum (Intensified HD)
The aim of this clinical research project is to test the hypothesis that daily dialysis has favorable effects on the calcification propensity of human serum, when determined by the investigators' newly developed in vitro serum test. The investigators' hypothesis is that shorter interdialytic intervals will result in an improved calcification propensity of serum. The determination of serum calcification has the potential to become a novel measure of dialysis quality in the future.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Hemodialysis Frequency and the Calcification Propensity of Serum|
- Change from baseline calcification propensity of serum [ Time Frame: 6 weeks ] [ Designated as safety issue: Yes ]
- Change from baseline of sodium, potassium, calcium, phosphate, magnesium, albumin, protein, hematocrit and their correlation with calcification propensity of serum [ Time Frame: 6 weeks ] [ Designated as safety issue: Yes ]
|Study Start Date:||January 2014|
|Estimated Study Completion Date:||January 2015|
|Estimated Primary Completion Date:||June 2014 (Final data collection date for primary outcome measure)|
Experimental: All study participants
Short daily dialysis for 2 weeks
|Procedure: Short daily dialysis for 2 weeks|
The serum calcification test has been established and validated by A. Pasch and coworkers, the expertise to perform the necessary statistical analyses is present in the investigator's department, all patient-related procedures necessary for this project are routinely performed in the investigator's department.
Does short daily hemodialysis strengthen the calcification-inhibitory forces inherent in hemodialysis patient sera, when compared to conventional three-times weekly hemodialysis?
Serum calcification test
|Dep. of Nephrology, Hypertension and Clinical Pharmacology, Bern University Hospital||Not yet recruiting|
|Bern, Switzerland, 3010|
|Contact: Anna Christen, Study Coordinator +41 (0)31 632 97 72 email@example.com|
|Principal Investigator: Andreas Pasch, PD. Dr. med.|
|Principal Investigator:||Andreas Pasch, PD. Dr. med.||University Clinic Inselspital Bern|