Postprandial VLDL-TG Metabolism

This study is not yet open for participant recruitment.
Verified October 2013 by University of Aarhus
Sponsor:
Information provided by (Responsible Party):
Esben Søndergaard, University of Aarhus
ClinicalTrials.gov Identifier:
NCT01961024
First received: September 27, 2013
Last updated: October 10, 2013
Last verified: October 2013
  Purpose

In thise study, we aim to determine the effect of meal fat on VLDL-TG kinetics in type 2 diabetic and healthy subjects matched for BMI in order to elucidate the potential pathophysiological differences in VLDL-TG FA channeling towards oxidation and storage in abdominal and leg subcutaneous adipose tissue. Specifically, we want to measure, by way of fat and muscle biopsies, the quantitative postprandial storage of VLDL-TG FA's in skeletal muscle and adipose tissue in relation to a series of tissue specific proteins and enzymes that might be involved in regulating skeletal muscle and adipose tissue FA storage.


Condition
Type 2 Diabetes

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Postprandial VLDL-TG Metabolism

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • VLDL-TG storage in adipose tissue [ Time Frame: 3 hours ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • 18F-THA fractional storage [ Time Frame: 6 Hours ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

specimen of muscle specimen of adipose tissue


Estimated Enrollment: 20
Study Start Date: January 2014
Estimated Primary Completion Date: January 2016 (Final data collection date for primary outcome measure)
Groups/Cohorts
Type 2 diabetic men
Age- and weight-matched controls

  Eligibility

Ages Eligible for Study:   30 Years to 70 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Males with diabetes from the department´s out-patient clinic. Control group of healthy volunteers

Criteria

Inclusion Criteria:

  • Written consent

Exclusion Criteria:

  • Known diseases
  • Alcohol abuse
  • Smoker
  • Regular use of medicine
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01961024

Contacts
Contact: Esben Søndergaard, MD, PhD +4578461631 esbens@dadlnet.dk

Locations
Denmark
Department of Endocrinology MEA, Aarhus Hospital Not yet recruiting
Aarhus C, Please Select, Denmark, 8000
Contact    4528730943      
Principal Investigator: Esben Søndergaard, MD, PhD         
Sponsors and Collaborators
University of Aarhus
  More Information

No publications provided

Responsible Party: Esben Søndergaard, Post Doc, MD, PhD, University of Aarhus
ClinicalTrials.gov Identifier: NCT01961024     History of Changes
Other Study ID Numbers: ES-0006
Study First Received: September 27, 2013
Last Updated: October 10, 2013
Health Authority: Denmark: Danish Dataprotection Agency

Keywords provided by University of Aarhus:
VLDL-TG kinetics
Postprandial state
Obesity

Additional relevant MeSH terms:
Diabetes Mellitus, Type 2
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases

ClinicalTrials.gov processed this record on April 16, 2014