The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population
Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population. Methods: Patients receiving elective surgery under general anesthesia were recruited into this study. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). The visual analog scale (VAS) was used for pain evaluation at rest and move after the operation. And the PCA press frequency and drug consumption were recorded. Also there were healthy college students volunteer be recruited into this study. The investigators measured their experimental pain sensitivity including pressure pain threshold (PPT) and pressure pain tolerance (PTO). Then genotyping was carried out by direct sequencing.
|Study Design:||Time Perspective: Prospective|
|Official Title:||The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population|
- Preoperative Pressure Pain Threshold (PPT) [ Time Frame: 30 minutes before the operation ] [ Designated as safety issue: Yes ]
- Preoperative Pressure Pain Tolerance (PTO) [ Time Frame: 30 minutes before the operation ] [ Designated as safety issue: Yes ]
Biospecimen Retention: Samples With DNA
Heparin anti-coagulated blood (5 ml) was collected from the periphery venous of subjects and all blood samples were stored at -80℃. Genomic DNA was extracted from the blood samples using a guanidinium isothiocyanate method.
|Study Start Date:||August 2013|
|Estimated Study Completion Date:||October 2015|
|Estimated Primary Completion Date:||August 2015 (Final data collection date for primary outcome measure)|
grouped by receiving surgery
Healthy volunteers group
grouped by healthy college students
Subjects with the following diseases were excluded: known history of chronic disease, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, Pregnancy or at lactation period .
Please refer to this study by its ClinicalTrials.gov identifier: NCT01950078
|Contact: Zhang Xianwei, MDfirstname.lastname@example.org|
|Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology||Recruiting|
|Wuhan, Hubei, China, 430030|
|Contact: Zhang Caie, MD email@example.com|
|Principal Investigator: Duan Guangyou, MD|
|Study Director:||Zhang Xianwei, MD||Huazhong University of Science and Technology|