Cardiac MRI in Ischemic Stroke Study (CaMriSS)

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2014 by Charite University, Berlin, Germany
Sponsor:
Collaborators:
Center for Stroke Research Berlin
Neurology, Charite University, Berlin, Germany
Cardiology and Angiology, Elisabeth Hospital, Essen, Germany
Information provided by (Responsible Party):
Karl Georg Haeusler, Charite University, Berlin, Germany
ClinicalTrials.gov Identifier:
NCT01917955
First received: August 7, 2012
Last updated: May 21, 2014
Last verified: May 2014
  Purpose

The purpose of this prospective single-center trial is to compare the safety and diagnostic value of contrast medium-enhanced cardiac magnetic resonance imaging and transesophageal echocardiography in patients with acute ischemic stroke.


Condition
Stroke

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Cardiac MRI in Ischemic Stroke Study

Further study details as provided by Charite University, Berlin, Germany:

Primary Outcome Measures:
  • Sensitivity and specificity of contrast medium-enhanced cardiac magnetic resonance imaging to detect echocardiography-proven cardiac sources of embolism in patients with acute ischemic stroke. [ Time Frame: < 1 week after ischemic stroke ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Rate of unrecognised myocardial infarction detected by late gadolinium-enhanced cardiac MRI in patients with acute ischemic stroke. [ Time Frame: < 1 week after ischemic stroke ] [ Designated as safety issue: No ]

Estimated Enrollment: 103
Study Start Date: May 2014
Estimated Study Completion Date: December 2016
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Detailed Description:

Primary safety objective: Contrast medium-enhanced cardiac magnetic resonance imaging is safe in patients with acute ischemic stroke. Primary outcome: The diagnostic value of contrast medium-enhanced cardiac magnetic resonance imaging is comparable to transesophageal echocardiography in patients with acute ischemic stroke.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Overall, 103 patients with acute ischemic stroke detected by brain magnetic resonance imaging will be enrolled.

Criteria

Inclusion Criteria:

  • Patients with acute ischemic stroke detected by brain magnetic resonance imaging.

Exclusion Criteria:

  • Known atrial fibrillation or cardiac source of embolism
  • Severe aphasia
  • Acute infection or chronic inflammation
  • Severe arteriosclerosis or stenosis of brain-supplying arteries
  • Contraindications for magnetic resonance imaging or transesophageal echocardiography.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01917955

Contacts
Contact: Karl Georg Haeusler, MD +49 30 8445 4244 georg.haeusler@charite.de

Locations
Germany
Charité, Universitätsmedizin Berlin, Campus Benjamin Franklin Recruiting
Berlin, Germany, 12203
Contact: Karl Georg Haeusler, MD    +49 30 8445 4244    georg.haeusler@charite.de   
Contact: Claudia Kunze    49 30 8445 4118    c.kunze@charite.de   
Principal Investigator: Karl Georg Haeusler, MD         
Sub-Investigator: Prof. Jochen B Fiebach, MD         
Sub-Investigator: PD Andreas Morguet, MD         
Elisabeth Hospital Recruiting
Essen, Germany
Contact: Oliver Bruder, MD         
Principal Investigator: Oliver Bruder, MD         
Sponsors and Collaborators
Charite University, Berlin, Germany
Center for Stroke Research Berlin
Neurology, Charite University, Berlin, Germany
Cardiology and Angiology, Elisabeth Hospital, Essen, Germany
Investigators
Study Chair: Prof. Matthias Endres, MD Center for Stroke Research Berlin
Principal Investigator: Karl Georg Haeusler, MD Center for Stroke Research Berlin
  More Information

No publications provided

Responsible Party: Karl Georg Haeusler, MD, Charite University, Berlin, Germany
ClinicalTrials.gov Identifier: NCT01917955     History of Changes
Other Study ID Numbers: CaMriSS_CSB, EA4/073/10
Study First Received: August 7, 2012
Last Updated: May 21, 2014
Health Authority: Germany: Ministry of Health

Keywords provided by Charite University, Berlin, Germany:
MRI

Additional relevant MeSH terms:
Stroke
Cerebral Infarction
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Brain Infarction
Brain Ischemia

ClinicalTrials.gov processed this record on September 18, 2014