A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2014 by Medtronic Spinal and Biologics
Sponsor:
Information provided by (Responsible Party):
Medtronic Spinal and Biologics
ClinicalTrials.gov Identifier:
NCT01917825
First received: July 30, 2013
Last updated: June 2, 2014
Last verified: June 2014
  Purpose

The primary objectives of this clinical trial are to investigate the pharmacokinetics and safety of MDT-15 pellets in escalating sequential doses administered to different cohorts. Preliminary efficacy data will also be collected for assessment.


Condition Intervention Phase
Sciatica
Lumbosacral Radiculopathy
Drug: MDT-15
Phase 2

Study Type: Interventional
Study Design: Endpoint Classification: Pharmacokinetics Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: An Open-Label, Sequential, Dose Escalation Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy

Resource links provided by NLM:


Further study details as provided by Medtronic Spinal and Biologics:

Primary Outcome Measures:
  • Cmax [ Time Frame: 84 days ] [ Designated as safety issue: No ]
    The Pharmacokinetics profile (Cmax, Tmax, AUC0-t, and AUC0-∞) following administration of up to six MDT-15 pellets in escalating sequential doses to different cohorts will be evaluated.

  • Tmax [ Time Frame: 84 days ] [ Designated as safety issue: No ]
    The Pharmacokinetics profile (Cmax, Tmax, AUC0-t, and AUC0-∞) following administration of up to six MDT-15 pellets in escalating sequential doses to different cohorts will be evaluated.

  • AUC0-t [ Time Frame: 84 days ] [ Designated as safety issue: No ]
    The Pharmacokinetics profile (Cmax, Tmax, AUC0-t, and AUC0-∞) following administration of up to six MDT-15 pellets in escalating sequential doses to different cohorts will be evaluated.

  • AUC0-∞ [ Time Frame: 84 days ] [ Designated as safety issue: No ]
    The Pharmacokinetics profile (Cmax, Tmax, AUC0-t, and AUC0-∞) following administration of up to six MDT-15 pellets in escalating sequential doses to different cohorts will be evaluated.

  • Incidence of Adverse Events [ Time Frame: 364 days ] [ Designated as safety issue: Yes ]
    Incidence of Adverse Events as a Measure of Safety.


Secondary Outcome Measures:
  • Change in Radicular Leg Pain [ Time Frame: Baseline and 364 days ] [ Designated as safety issue: No ]
    Radicular leg pain measured by a 0-10 Numeric Rating Scale (NRS).

  • Change in Physical Function [ Time Frame: Baseline and 364 days ] [ Designated as safety issue: No ]
    Physical Functioning measured by the Modified Roland Disability Questionnaire (RMS-L).

  • Change in Back Pain [ Time Frame: Baseline and 364 days ] [ Designated as safety issue: No ]
    Back pain measured by a 0-10 Numeric Rating Scale (NRS).

  • Change in Neuropathic Type Symptoms [ Time Frame: Baseline and 84 days ] [ Designated as safety issue: No ]
    Neuropathic Type Symptoms as measured by the Short-form McGill Pain Questionnaire (SF-MPQ-2).

  • Change in Medical Outcomes study - Sleep Scale [ Time Frame: Baseline and 84 days ] [ Designated as safety issue: No ]
    Sleep as measured by the Medical Outcomes Study - Sleep Scale (MOS-Sleep).

  • Change in Emotional Function [ Time Frame: Baseline and 84 days ] [ Designated as safety issue: No ]
    Emotional functioning as measured by the Profile of Mood States - Brief Form (POMS- Brief).

  • Change in Work Function [ Time Frame: Baseline and 84 days ] [ Designated as safety issue: No ]
    Work Function as measured by the Work Limitations Questionnaire (WLQ).

  • Global Rating of Improvement [ Time Frame: 84 days ] [ Designated as safety issue: No ]
    Global rating of improvement as measured by a Patient Global Impression of Change (PGIC).


Estimated Enrollment: 54
Study Start Date: July 2013
Estimated Study Completion Date: January 2016
Estimated Primary Completion Date: January 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: MDT-15
The treatments will be administered to separate, sequential cohorts of 18 treated subjects in the following escalating doses:1 pellet, 3 pellets, and 6 pellets.
Drug: MDT-15

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Be male or female at least 18 years of age.
  2. Have radiating pain toward the buttock down to the leg and/or feet, unilateral.
  3. Have radiologic pathology change from L1 - S1 consistent with a disc protrusion, non-sequestered extrusion, or sequestered fragment, as evidenced by magnetic resonance imaging (MRI), that is consistent with the clinical signs and symptoms of lumbar radiculopathy. The MRI must have been performed within 2 months prior to screening or it will need to be repeated.
  4. Have primary leg pain with an average NRS score equal to or greater than 5 as measured twice a day for five days in each of two weeks during screening.
  5. Have failed conservative care for at least 6 weeks. The subject must have been treated non-operatively (e.g., bed rest, physical therapy, medications, TENS, and/or manipulation) for a period of at least 6 weeks.
  6. Be willing to stop current anti-inflammatory therapy taken for treatment of radicular pain.
  7. Be willing and able to keep a diary that will record study-related information.
  8. If sexually active female of childbearing potential, be willing to use an acceptable method of birth control during the study. Acceptable methods include oral contraceptives (the pill), IUDs, contraceptive implants under the skin, contraceptive rings or patches or injections, diaphragms with spermicide, and condoms with spermicide. Surgical sterilization by tubal ligation or hysterectomy is acceptable. Women of child bearing potential are defined as women who are <12 months since their last menstrual cycle prior to screening and have not experienced surgical menopause.
  9. Be able to understand the study and provide written informed consent.

Exclusion Criteria:

  1. Have a history of lumbar surgery, including vertebroplasty and kyphoplasty.
  2. Be ≤ 6 weeks after lumbar ESI or nerve block at start of screening.
  3. Have current radicular pain for more than 6 months.
  4. Have more than one epidural steroid injection at the affected level to be treated within the last 6 months.
  5. Have demonstrated radiographic changes consistent with subject's symptoms at more than one level on the baseline MRI.
  6. Have symptomatic spinal stenosis of central origin at any level based on CT myelogram or MRI.
  7. Have pain that is localized in the lower back or other sites and is a greater component of the subject's total pain than the pain in the lower leg and/or foot.
  8. Have physical problems that may interfere with any study assessments.
  9. Have known infection with human immunodeficiency virus, hepatitis B virus, or hepatitis C virus.
  10. Have presence of local or systemic malignant disease or history of local or systemic malignant disease in the past 5 years (history of basal cell carcinoma will be allowed).
  11. Have impaired renal function (creatinine >1.5 times upper limit of normal).
  12. Have chronic impairment liver function (aspartate aminotransferase [AST] or alanine aminotransferase [ALT] >3 times upper limit of normal).
  13. Have insulin-dependent diabetes or uncontrolled diabetes mellitus (glycosylated hemoglobin [HbA1c] >7%).
  14. Have leukopenia (<3,500 leukocytes/uL).
  15. Have current orthostatic hypotension (defined as systolic blood pressure decrease of at least 20 mmHg or a diastolic blood pressure decrease of at least 10 mmHg or an increase in heart rate by 20 beats per minute within 3 minutes of standing).
  16. Have clinically significant risk for hypotension (e.g., hypotension defined as systolic reading <90 mmHg and/or diastolic <60 mmHg, hypovolemia, autonomic neuropathy, or other medical conditions affected by changes in blood pressure).
  17. Any clinically significant cardiovascular condition as evidenced by physical exam, medical history and/or baseline electrocardiogram (ECG).
  18. Have evidence of bradycardia as shown by heart rate of <60 beats per minute via screening ECG.
  19. Have any poorly-controlled or serious medical condition, psychiatric illness, or clinically significant laboratory value that, in the opinion of the investigator, could compromise the safety of the subject or the scientific integrity of the study (e.g., uncontrolled hypertension, autoimmune disease, or clinically relevant symptoms of thyroid dysfunction).
  20. Have cauda equina syndrome.
  21. Have neurological deficits, as determined by the investigator, which would interfere with the assessments required by the protocol.
  22. Have been previously diagnosed with peripheral neuropathy.
  23. Have vascular claudication, as determined by the investigator, which would interfere with the assessments required by the protocol.
  24. Have a history or evidence of bleeding disorder (e.g., hemophilia, disseminated intravascular coagulation disorder [DIC], or thrombocytopenia [TCP])
  25. Have greater than 3 mm spondylolisthesis at the affected level.
  26. Have BMI greater than or equal to 40, or with any anatomic issues that may interfere with placement of the MDT-15 pellets as noted by the Investigator.
  27. Have a diagnosis of major depression.
  28. Have sustained a vertebral or hip fracture within the last year.
  29. Have known or suspected allergy or hypersensitivity to clonidine, lidocaine, contrast media, opioids, any medication that may be given as part of the site's standard of care related to the study drug implantation procedure, or any other medication that may be given as treatment during the study.
  30. Have a known or suspected allergy to polylactic acid (found in products such as Lupron Depot®, Atridox®, some types of dermal fillers, and some types of sutures).
  31. If female, be pregnant or breastfeeding, or desiring to become pregnant during the trial.
  32. Have taken an investigational drug or used an investigational device within the past 30 days or intending to use an investigational drug or device during the trial.
  33. Have active alcoholism or drug dependency, as determined by the investigator
  34. Be currently on worker's compensation or in litigation related to injury or medical condition.
  35. Be in circumstances which make it difficult to maintain a usual nighttime sleep schedule (e.g., the subject works on an evening/night shift or otherwise has a work or activity schedule which could confound or interfere with study assessments).
  36. Have current treatment with any of the following medications:

    1. Systemic corticosteroids (intranasal/inhaled steroids are acceptable).
    2. Immunosuppressant therapy to treat autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis).
    3. Oral or topical products that contain clonidine (e.g., Catapres).
    4. Herbal supplements that contain yohimbine.
    5. Anti-coagulant therapy (prophylactic aspirin at 81mg/day is acceptable). If applicable, aspirin therapy should be held before and after the study procedure based on the investigator's discretion.
    6. Calcium channel blocker, digoxin, or beta-adrenergic blockers.
  37. Have chronic use of opioids (including tramadol), defined as use 20 out of the last 30 days prior to study screening.
  38. Have emotional or health concerns (in the judgment of the investigator) that may compromise the safety of the subject, may make compliance difficult, or may confound the reliability of information acquired in this study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01917825

Contacts
Contact: Clinical Department 1800-876-3133 ext 6068 msbkclinicalresearch@medtronic.com

Locations
United States, Florida
Holy Cross Orthopedic Institute Recruiting
Ft Lauderdale, Florida, United States, 33334
Contact: Suzanne Whisner    954-958-4822      
Principal Investigator: W Porter McRoberts, MD         
United States, Illinois
Millennium Pain Center Recruiting
Bloomington, Illinois, United States, 61701
Contact: Sara Ditchen    309-662-4321      
Principal Investigator: Ramsin Benyamin, MD         
United States, Indiana
Indiana Spine Group Recruiting
Carmel, Indiana, United States, 46032
Contact: Sheetal Vinayek    317-715-5897      
Principal Investigator: Kevin Macadaeg, MD         
Franciscan St Francis Pain and Spine Center Recruiting
Indianapolis, Indiana, United States, 46237
Contact: Katrina Yaggi    317-528-7821      
Principal Investigator: Robert Prince, MD         
United States, Kentucky
Otrimed Clinical Research Recruiting
Edgewood, Kentucky, United States, 41017
Contact: Patricia Shay    859-757-1359      
Principal Investigator: Pragya Gupta, MD         
United States, West Virginia
Center for Pain Relief Withdrawn
Charleston, West Virginia, United States, 25301
Sponsors and Collaborators
Medtronic Spinal and Biologics
  More Information

No publications provided

Responsible Party: Medtronic Spinal and Biologics
ClinicalTrials.gov Identifier: NCT01917825     History of Changes
Other Study ID Numbers: P12-06
Study First Received: July 30, 2013
Last Updated: June 2, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Medtronic Spinal and Biologics:
radicular pain

Additional relevant MeSH terms:
Radiculopathy
Nervous System Diseases
Neuromuscular Diseases
Peripheral Nervous System Diseases

ClinicalTrials.gov processed this record on October 21, 2014