Trial record 6 of 150 for:    Open Studies | "Endometrial Neoplasms"

Ponatinib in the Treatment of FGFR Mutation Positive Recurrent or Persistent Endometrial Carcinoma

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified August 2014 by Washington University School of Medicine
Sponsor:
Information provided by (Responsible Party):
Washington University School of Medicine
ClinicalTrials.gov Identifier:
NCT01888562
First received: June 25, 2013
Last updated: August 15, 2014
Last verified: August 2014
  Purpose

To test the patient's cancerous tumor to see if it has a FGFR mutation and, if so, to see how their cancer responds to a treatment with the drug ponatinib as well as examine the side effects caused by ponatinib.


Condition Intervention
Endometrial Neoplasms
Drug: Ponatinib

Study Type: Interventional
Study Design: Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Pilot Evaluation of Ponatinib (AP24534), a Potent Oral Pan-FGFR Inhibitor, in the Treatment of FGFR Mutation Positive Recurrent or Persistent Endometrial Carcinoma: a Multi-Institutional Study

Resource links provided by NLM:


Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:
  • Tumor responses (CR + PR) [ Time Frame: 6 months ] [ Designated as safety issue: No ]

    Ponatinib in patients with recurrent or persistent endometrioid endometrial cancer (FGFR2 activating mutation positive)for tumor responses (CR + PR)

    Complete Response (CR): Disappearance of all target lesions. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to <10 mm.

    Partial Response (PR): At least a 30% decrease in the sum of the diameters of target lesions, taking as reference the baseline sum diameters.


  • Progression Free survival [ Time Frame: 6 months ] [ Designated as safety issue: No ]

    Ponatinib in patients with recurrent or persistent endometrioid endometrial cancer (FGFR2 activating mutation positive) by evaluating progression-free survival

    Progression-free survival is defined as the duration of time from start of treatment to time of progression or death, whichever occurs first.



Secondary Outcome Measures:
  • Progression Free Survival [ Time Frame: 5.5 years ] [ Designated as safety issue: No ]
    Progression Free Survival is defined as the duration of time from start of treatment to time of progression or death, whichever occurs first.

  • overall survival [ Time Frame: 5.5 years ] [ Designated as safety issue: No ]
    Overall survival is define as date from time of initial treatment to date of death from any cause.

  • Toxicity of Ponatinib [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
    Frequency and severity as defined by CTCAE v 4.0


Estimated Enrollment: 15
Study Start Date: October 2014
Estimated Study Completion Date: February 2021
Estimated Primary Completion Date: February 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Ponatinib
Ponatinib 45mg po daily for 4 weeks (4 weeks equal 1 cycle).
Drug: Ponatinib
Ponatinib 45 mg daily for 4 weeks (4 weeks equal one cycle)
Other Name: Iclusig™

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients must have recurrent or persistent endometrial carcinoma which is refractory to curative therapy or established treatments. Histologic confirmation of the original primary tumor is required. Patients with the following histologic epithelial cell types are eligible: endometrioid adenocarcinoma.
  • All patients must have measurable disease. Measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest dimension to be recorded). Each lesion must be ≥ 20 mm when measured by conventional techniques, including palpation, plain x-ray, CT, and MRI, or ≥ 10 mm when measured by spiral CT.

Patients must have at least one "target lesion" to be used to assess response on this protocol as defined by RECIST 1.1 (Section 11.1). Tumors within a previously irradiated field will be designated as "non-target" lesions unless progression is documented or a biopsy is obtained to confirm persistence at least 90 days following completion of radiation therapy.

  • Patients must have a documented FGFR2 activating mutation either on primary, recurrent or metastatic biopsy. Over 90% of FGFR2 mutations occur at 7 codons. Activating mutations are defined as the known FGFR2 hotspots at S252W, P253R, S373C, Y376C, C383R, N550K, N550H, K660E.
  • Patients who have received one or two prior regimen must have a GOG Performance Status of 0, 1, or 2. Patients who have received three prior regimens must have a GOG Performance Status of 0 or 1.
  • Patients must be ≥ 18 years of age.
  • Patients must be able to swallow tablets.
  • Patients must have recovered from the effects of recent surgery, radiotherapy, or chemotherapy.
  • Patients should be free of active infection requiring antibiotics (with the exception of uncomplicated UTI).
  • Any hormonal therapy directed at the malignant tumor must be discontinued at least one week prior to registration.
  • Any other prior therapy directed at the malignant tumor, including immunologic agents, must be discontinued at least three weeks prior to registration.
  • Patients must have had at least one prior chemotherapeutic regimen for management of endometrial carcinoma. Chemotherapy administered in conjunction with primary radiation as a radio-sensitizer will be counted as a systemic chemotherapy regimen. Patients may have received prior anti-angiogenic compounds (i.e., bevacizumab).

Patients are allowed to receive, but are not required to receive, up to two additional cytotoxic regimens for management of recurrent or persistent endometrial disease according to the following definition:

Cytotoxic regimens include any agent that targets the genetic and/or mitotic apparatus of dividing cells, resulting in dose-limiting toxicity to the bone marrow and/or gastrointestinal mucosa.

  • Patients must have adequate bone marrow function defined as:

    • Absolute neutrophil count (ANC) ≥ 1,500/mcl
    • Platelets ≥ 100,000/mcl
    • Hemoglobin > 9 g/dl
  • Patients must have adequate renal function defined as:

    • Creatinine ≤ 1.5 x institutional upper limit normal (ULN)

  • Proteinuria must be ≤ 3+ by dipstick at baseline. If the urine dipstick is > 3+, a 24-hour protein level must be performed. The 24-hour protein level must be ≤ 3.5 g/24 hours.
  • Patients must have adequate hepatic function defined as:

    • Bilirubin ≤ 1.5 x ULN
    • AST (SGOT), ALT (SGPT), and alkaline phosphatase ≤ 2.5 x ULN
    • Albumin ≥ 2.5 g/dl
  • Patients must have adequate neurologic function defined as:

    • Neuropathy (sensory and motor) ≤ grade 1

  • Patients must have adequate blood coagulation parameters defined as:

    • PT such that international normalized ratio (INR) is ≤ 1.5

Patients on therapeutic warfarin are excluded from trial; anticoagulation with a heparin or heparin-like compound is permitted provided patient's PT INR is ≤ 1.5.

  • Patients must be able to understand and willing to sign an approved informed consent and authorization permitting release of personal health information.
  • Patients of childbearing potential must have a negative serum pregnancy test performed 48 hours prior to first dose and be practicing an effective form of contraception during the study and for at least 3 months after receiving the final treatment of ponatinib. Effective contraception is defined as hormonal or barrier method, or abstinence.
  • Patients must have a baseline electrocardiogram completed prior to study entry with QTc ≤ 450 msec. Baseline ECG should be repeated if QTc is found to be > 450 msec. QTc must NOT be > 450 msec on both ECGs performed during the same visit.

Exclusion Criteria:

  • Patients must not have had prior therapy with ponatinib or anti-FGFR (fibroblast growth factor receptor) therapy including brivanib, BIBF1120, and E7080.
  • Patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer, localized cancer of the breast, and localized cancer of the head and neck, are excluded if there is any evidence of the other malignancy being present within the last five years. Patients are also excluded if their previous cancer treatment contraindicates this protocol therapy.
  • Patients who have received prior radiotherapy to any portion of the abdominal cavity or pelvis OTHER THAN for the treatment of endometrial cancer within the last five years are excluded. Prior radiation for localized cancer of the breast, head and neck, or skin is permitted, provided that it was completed more than three years prior to registration, and the patient remains free of recurrent or metastatic disease.
  • Patients who have received prior chemotherapy for any abdominal or pelvic tumor OTHER THAN for the treatment of endometrial cancer within the last five years are excluded. Patients may have received prior adjuvant chemotherapy for localized breast cancer, provided that it was completed more than three years prior to registration, and that the patient remains free of recurrent or metastatic disease.
  • Patients must not be on required chronic anti-platelet therapy (aspirin >300 mg/day, or clopidogrel greater than or equal to 75mg/day).
  • Patients must not have any gastrointestinal bleeding or any other hemorrhage/bleeding event ≥ grade 3 within 30 days prior to study entry.
  • Patients must not have a history of poor wound healing, non-healing ulcers or bone fractures within the last 3 months.
  • Patients must not have uncontrolled or significant cardiovascular disease including:

    • Myocardial infarction within 3 months
    • Uncontrolled angina within 3 months
    • Class III-IV New York Heart Association (NYHA) congestive heart failure (see Appendix B)
    • Uncontrolled hypertension (systolic BP > 150 or diastolic BP > 100 mmHg for 24 hours) despite optimized anti-hypertensive therapy. BP must be below 150/100 mmHg at screening. Subjects with a history of hypertension who are receiving treatment with calcium channel blockers that are CYP3A4 inhibitors should be changed to an alternative antihypertensive medication before study entry
    • History of stroke, TIA, or other CNS ischemic event
    • Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta blockers or digoxin
    • Pre-therapy Left Ventricle Ejection Fraction (LVEF) ≤ 50%
    • Valvular heart disease ≥ grade 2
  • Patients must not have a serious uncontrolled medical disorder or active infection which would impair the ability of the subject to receive protocol therapy or whose control may be jeopardized by the complications of this therapy.
  • Patients must not have any pre-existing thyroid abnormality with thyroid function that cannot be maintained in the institutional normal range with medication.
  • Patients must not have hyponatremia (sodium < 130mEq/L).
  • Patients must not have active/known HIV, Hepatitis B, or Hepatitis C.
  • Patients must not have known brain metastases. Patients with known brain metastases will be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurological dysfunction that would confound the evaluation of neurologic and other adverse events.
  • Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biological composition to ponatinib or other agents used in this study.
  • Patients must not be pregnant or nursing.
  • Patients must not have untreated malabsorption syndrome.
  • Patients must not have baseline serum potassium < 3.5 mmol/L (potassium supplementation may be given to restore the serum potassium above this level prior to study entry).
  • Patients on therapeutic warfarin anticoagulation will be excluded. Patients converted to anticoagulation with a heparin compound will be allowed provided the PT INR is ≤ 1.5.
  • Patients with:

    1. History of acute pancreatitis within 1 year of study or history of chronic pancreatitis
    2. History of alcohol abuse
    3. History of uncontrolled hypertriglyceridemia (triglycerides > 450 mg/dL)
  • Women and Minorities

Participating institutions will not exclude potential subjects from participating in this or any study solely on the basis of ethnic origin or socioeconomic status. Every attempt will be made to enter all eligible patients into this protocol and therefore address the study objectives in a patient population representative of the entire endometrial cancer population treated by participating institutions.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01888562

Contacts
Contact: Matthew Powell, M.D. 314-362-3181 mpowell@wustl.edu

Locations
United States, Missouri
Washington University School of Medicin Not yet recruiting
St. Louis, Missouri, United States, 63110
Contact: Matthew Powell, M.D.    314-362-3181    mpowell@wustl.edu   
Sub-Investigator: David Mutch, M.D.         
Sub-Investigator: L. Steward Massad, M.D.         
Sub-Investigator: Premal Thaker, M.D.         
Sub-Investigator: Andrea Hagemann, M.D.         
Sub-Investigator: John Pfeifer, M.D., Ph.D.         
Sub-Investigator: Ian Hagemann, M.D., Ph.D.         
Sub-Investigator: Nancy Tecu, AOCNP         
Sponsors and Collaborators
Washington University School of Medicine
  More Information

Additional Information:
No publications provided

Responsible Party: Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT01888562     History of Changes
Other Study ID Numbers: 201404024
Study First Received: June 25, 2013
Last Updated: August 15, 2014
Health Authority: United States: Inistitutional Review Board

Additional relevant MeSH terms:
Endometrial Neoplasms
Neoplasms
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Uterine Neoplasms
Genital Neoplasms, Female
Urogenital Neoplasms
Neoplasms by Site
Uterine Diseases
Genital Diseases, Female
Ponatinib
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on August 28, 2014