Correlations of 3D Urethral and Paraurethral Sonographic Findings With Urodynamic Studies, Lower Urinary Tract Symptoms & Sexual Dysfunction in Female Patients With Lower Urinary Tract Syndromes
Female lower urinary tract dysfunction includes stress urinary incontinence, overactive bladder syndrome and voiding dysfunction. There are a lot of bladder studies, such as researches of bladder wall thickness and bladder volume. However, there were few studies of urethra for female patients with lower urinary tract symptoms (LUTS), especially for storage disorder. Thus, the main purpose of this study is to get the urethra and pelvic sonographic imaging by 4D ultrasound examinations, and to correlate the sonographic findings with urodynamic variables, pad weights and LUTS. The investigators hope to identify important LUTS sonographic biomarkers that can be used by primary physicians as a tool for assess female LUTS, and thus decreasing the need of further invasive urodynamic studies. Besides, the associations of the blood flow of vagina/urethra and sexual dysfunction can be explored.
Lower Urinary Tract Dysfunction
Overactive Bladder Syndrome
|Study Type:||Observational [Patient Registry]|
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Target Follow-Up Duration:||12 Weeks|
|Official Title:||Correlations of 3D Urethral and Paraurethral Sonographic Findings With Urodynamic Studies, Lower Urinary Tract Symptoms & Sexual Dysfunction in Female Patients With Lower Urinary Tract Syndromes.|
- Urethral/pelvic blood flow perfusion pattern between subgroups of women with lower urinary tracts [ Time Frame: 1 day ] [ Designated as safety issue: No ]We will get the associations of urethral/pelvic blood flow perfusion pattern between subgroups of women with lower urinary tracts, and the above results will be compared to that of the asymptomatic control group.
- Urethral/pelvic blood flow perfusion pattern after antimuscrinics [ Time Frame: 12 months ] [ Designated as safety issue: No ]We will compare the urethral/pelvic blood flow perfusion pattern between the baseline and 12 weeks' antimuscarinic treatment (solifenacin 5 mg SR qd or tolerodine 4 mg ER qd) in women with overactive bladder syndrome.
- The subgroup differences of urethral/pelvic volume, hiatal area and rupture of puborectalis muscles [ Time Frame: 1 day ] [ Designated as safety issue: No ]we will use 4 D ultrasound to assess the urethral/pelivc volume, hiatal area and rupture of puboractalis muscles among subgroups of women with lower urinary tract symptoms, and the above results will be compared to that of the control group. Besides, the correlation of imaging findings and clinical symptoms (such as lower urinary tract symptoms and sexual dysfunction) will be compared.
|Study Start Date:||June 2013|
|Estimated Study Completion Date:||December 2016|
|Estimated Primary Completion Date:||October 2016 (Final data collection date for primary outcome measure)|
|Contact: Shen-Mou Hsiao, MD||+886-2-89667000 ext email@example.com|
|Far Eastern Memorial Hospital||Recruiting|
|New Taipei, Taiwan, 220|
|Contact: Sheng-Mou Hsiao, MD +886-2-89667000 ext 1424 firstname.lastname@example.org|
|Principal Investigator: Sheng-Mou Hsiao, MD|
|Principal Investigator:||Sheng-Mou Hsiao, MD||Department of Obstetrics & Gynecology, Far Eastern Memorial Hospital|