Exercise-induced Hypoaglesia After Comparative Forms of Exercise

This study is currently recruiting participants.
Verified June 2013 by University of Wisconsin, Madison
Sponsor:
Information provided by (Responsible Party):
University of Wisconsin, Madison
ClinicalTrials.gov Identifier:
NCT01883895
First received: June 12, 2013
Last updated: June 18, 2013
Last verified: June 2013
  Purpose

The study involves recording response to discomfort following different forms of exercise. We think that there will be a increased pain tolerance following exercise but are unsure if there will be a difference between exercises.


Condition Intervention
Pain
Device: Forgioni-Barber pressure-pain stimulator
Other: Concentric Exercise
Other: isometric exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Exercise-induced Hypoaglesia After Comparative Forms of Anaerobic Training in Healthy Adults

Resource links provided by NLM:


Further study details as provided by University of Wisconsin, Madison:

Primary Outcome Measures:
  • Pain intensity ratings [ Time Frame: Ratings will be recorded at 20 second intervals following each administration of the pressure stimulator. ] [ Designated as safety issue: No ]
    Subjects will rate pain intensity using a 0 (no pain) to 100 (most intense pain imaginable) pain rating scale before and after application of a validated pressure stimulator immediately prior to, and after exercise.


Secondary Outcome Measures:
  • Pain Threshold [ Time Frame: We will monitor the subject's reported pain thresholds during the two minute interval that the pressure stimulus is applied. Expected average is less than one minute. ] [ Designated as safety issue: No ]
    Subjects will press a button attached to a timer out of view of the subject when the pressure stimulus first becomes painful. This will utilize a protocol recognized as a validated measurement of pain threshold.


Estimated Enrollment: 32
Study Start Date: June 2013
Estimated Study Completion Date: June 2014
Estimated Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Concentric exercise
Concentric exercise will utilize a dumbbell with elbow flexion exercise.
Device: Forgioni-Barber pressure-pain stimulator
Pain testing will be conducted using a Forgioni-Barber pressure-pain stimulator to deliver 3000-gm force to the middle digit of the non-dominant middle finger for up to 120 seconds. During stimulation, subjects will press a button attached to a timer when the pressure stimulus first becomes painful (pain threshold) and will also rate their perceived pain intensity using a 0-100 numeric pain rating scale at 20 second intervals during the 2 minute exposure to the pressure stimulus. This validated protocol has been used in previous research by investigators in this study.
Other: Concentric Exercise
Concentric testing will utilize a dumbbell with elbow flexion exercise. Subjects will perform 5 sets of 20 reps at 30% MVC. Pain testing will be conducted using a Forgioni-Barber pressure-pain stimulator immediately before and after the exercise.
Experimental: isometric exercise
Subjects will perform 5 sets of sustained muscle contraction.
Device: Forgioni-Barber pressure-pain stimulator
Pain testing will be conducted using a Forgioni-Barber pressure-pain stimulator to deliver 3000-gm force to the middle digit of the non-dominant middle finger for up to 120 seconds. During stimulation, subjects will press a button attached to a timer when the pressure stimulus first becomes painful (pain threshold) and will also rate their perceived pain intensity using a 0-100 numeric pain rating scale at 20 second intervals during the 2 minute exposure to the pressure stimulus. This validated protocol has been used in previous research by investigators in this study.
Other: isometric exercise
When undergoing isometric exercise, subjects will perform 5 sets of sustained muscle contraction for 65 seconds using a hand-grip dynamometer. Pain testing will be conducted using a Forgioni-Barber pressure-pain stimulator immediately before and after the exercise.
Active Comparator: Control
Subjects will undergo a control arm where they will rest for approximately 10 minutes.
Device: Forgioni-Barber pressure-pain stimulator
Pain testing will be conducted using a Forgioni-Barber pressure-pain stimulator to deliver 3000-gm force to the middle digit of the non-dominant middle finger for up to 120 seconds. During stimulation, subjects will press a button attached to a timer when the pressure stimulus first becomes painful (pain threshold) and will also rate their perceived pain intensity using a 0-100 numeric pain rating scale at 20 second intervals during the 2 minute exposure to the pressure stimulus. This validated protocol has been used in previous research by investigators in this study.

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • normotensive
  • age range 18 to 40 years

Exclusion Criteria:

  • currently taking prescription medications
  • current use of tobacco or recreational drugs including opiates and/or marijuana
  • any chronic illness such as diabetes, cancer, fibromyalgia, or hypertension
  • upper limb musculoskeletal pain, injury, or surgery that will limit ability to exercise
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01883895

Contacts
Contact: ben rawson, DO 2168498685 rawson.rehab@gmail.com
Contact: nalini sehgal, MD 6082630102 sehgal@rehab.wisc.edu

Locations
United States, Wisconsin
University of Wisconsin Hospitals and Clinics Recruiting
Madison, Wisconsin, United States, 53705
Sponsors and Collaborators
University of Wisconsin, Madison
Investigators
Principal Investigator: Nalini Sehgal, MD University of Wisconsin Dept Ortho/Rehab
Study Director: ben rawson, DO University of Wisconsin Dept Ortho/Rehab
  More Information

No publications provided

Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT01883895     History of Changes
Other Study ID Numbers: 2012-0805
Study First Received: June 12, 2013
Last Updated: June 18, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by University of Wisconsin, Madison:
Pain
exercise-induced hypoalgesia

ClinicalTrials.gov processed this record on April 16, 2014