Phenylketonuria and Hyperphenylalaninemia Nutrition Study
The mainstay of PKU treatment is a low-phenylalanine diet (i.e restriction of natural protein), and supplementation with a protein substitute (a mixture of amino acids free from phenylalanine, also containing micronutrients and vitamins) and special low-protein foods, to meet the patient's energy requirements. When diet and treatment is relaxed after childhood, adult and adolescent patients with phenylketonuria are at risk for malnutrition, depending on the compliance with treatment and the intake of amino acid supplements.
In this study, nutrition status of patients with PKU and hyperphenylalaninemia is systematically assessed under ongoing current treatment, in relation to Phe-tolerance, compliance with treatment, and psychosocial issues.
Study participants do not undergo any specific therapeutic or diagnostic intervention.
Phenylketonuria (PKU) and Hyperphenylalaninemia
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Nutrition Status of Adult and Adolescent Patients With Classical Phenylketonuria (PKU) and Hyperphenylalaninemia|
- Macronutrient and micronutrient intake, calculated from a nutrition protocol (four consecutive days) [ Time Frame: assessed during 4 consecutive days max. within 1 month after a regular consultation in the outpatient clinic ] [ Designated as safety issue: No ]
Macronutrients: protein, fat, carbohydrates in g/kg/d
Daily phenylalanine and tyrosine intake Micronutrients and minerals: Calcium, magnesium, iron, zinc, selenium
Vitamins: D, B12, B6, C, folic acid
- Phenylalanine level (umol/l) [ Time Frame: assessed at the end of the four-day nutrition protocol (see primary outcome) ] [ Designated as safety issue: No ]this outcome measure is not study-specific and is collected as part of established routine care (self-measurement by patient)
- Plasma amino acid profile [ Time Frame: determined at a routine visit at the outpatient clinic, on average 1x per year ] [ Designated as safety issue: No ]this outcome measure is not study-specific and is collected as part of established routine care.
- Concentrations of micronutrients, minerals and vitamins [ Time Frame: determined at a routine visit at the outpatient clinic, on average 1x per year ] [ Designated as safety issue: No ]
assessed parameters: Ferritin, zinc, selenium, vitamin D, vitamin B12, folic acid.
These outcome measures are not study-specific and are collected as part of established routine care
- body weight (kg) [ Time Frame: determined at a routine visit at the outpatient clinic, on average once every 6 - 12 months ] [ Designated as safety issue: No ]assessed as part of routine clinical care
|Study Start Date:||June 2013|
|Estimated Study Completion Date:||July 2015|
|Estimated Primary Completion Date:||July 2015 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01879995
|Contact: Michel Hochuli, MD PhDfirstname.lastname@example.org|
|University Hospital Zurich, Division of Endocrinology, Diabetes and Clinical Nutrition||Recruiting|
|Zurich, ZH, Switzerland, 8091|
|Contact: Michel Hochuli, MD PhD 0041 44 255 86 26 email@example.com|
|University Children's Hospital||Not yet recruiting|
|Zurich, Switzerland, CH-8032|
|Contact: Matthias Baumgartner, MD firstname.lastname@example.org|
|Principal Investigator: Matthias Baumgartner, MD|
|Principal Investigator:||Michel Hochuli, MD PhD||University Hospital Zurich, Division of Endocrinology, Diabetes and Clinical Nutrition|