Blood Cell Response to Exercise
Moderate exercise is recommended to improve cardiovascular health in obese and overweight people particularly with metabolic syndrome (MetS) that have hypertension, elevated fasting blood sugar, and elevated blood lipids. This study is being done to determine how platelets respond when a person performs an initial period of moderate exercise.
|Study Design:||Intervention Model: Single Group Assignment|
|Official Title:||Blood Cell Response to Exercise|
- Platelet Reactivity [ Time Frame: Baseline, post-intervention (24 hours), & time points during the exercise phase: prior to exercise (-25 min, -10 min, - 1 min), 10 minutes into the routine, at completion (25 minutes), and 20 & 60 minutes following completion ]We hypothesize that moderate physical exercise will increase platelet reactivity in sedentary individuals with metabolic syndrome. Platelet reactivity will be measured by flow cytometry using anti-CD61 antibodies as a marker for platelets and anti-CD62 (P-selectin) as a marker of platelet activation. This will be measured at baseline, post-intervention and time points post-baseline in each subject.
|Study Start Date:||February 2013|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
Other: Moderate Physical Exercise
Please refer to this study by its ClinicalTrials.gov identifier: NCT01872273
|Contact: Angela Scheett, MPH, RDfirstname.lastname@example.org|
|United States, North Dakota|
|Grand Forks Human Nutrition Research Center||Recruiting|
|Grand Forks, North Dakota, United States, 58201|
|Contact: Angela Scheett, MPH, RD 701-795-8386 email@example.com|
|Principal Investigator: Matthew Picklo, PhD|
|Principal Investigator:||Matthew Picklo, PhD||USDA Grand Forks Human Nutiriton Center|