Study of Pain Management Techniques Following Anterior Cruciate Ligament Repair Surgery

This study is not yet open for participant recruitment.
Verified May 2013 by Lawson Health Research Institute
Sponsor:
Information provided by (Responsible Party):
Sugantha Ganapathy, Lawson Health Research Institute
ClinicalTrials.gov Identifier:
NCT01868282
First received: April 26, 2013
Last updated: May 30, 2013
Last verified: May 2013
  Purpose

Patients scheduled to undergo knee arthroscopy with anterior cruciate ligament repair with graft from the ipsilateral hamstrings and gracilis will be randomized to one of three groups. All patients will receive subsartorial saphenous nerve block. Along with this, Group 1 will receive perihamstring local anesthetic infiltration (Hamstring block), Group 2 will receive blockade of the anterior division of obturator nerve and Group 3 (control group) will receive sham injections of hamstrings and anterior division obturator nerve. All patients will receive co-analgesics for home discharge. The study will evaluate the efficacy of subsartorial saphenous nerve block alone or in combination with either hamstring block or obturator block with regards to postoperative analgesia especially the donor site pain and total analgesic consumption.


Condition Intervention Phase
Anterior Cruciate Ligament Reconstruction
Procedure: Hamstrings block
Procedure: Obturator block
Procedure: Control group
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver)
Primary Purpose: Treatment
Official Title: Comparison of Efficacy and Safety of Perihamstring Local Anesthetic Injection to Obturator Nerve Block When Combined With Subsartorial Saphenous Block for Anterior Cruciate Ligament Repair. A Randomized Double Blinded Study.

Resource links provided by NLM:


Further study details as provided by Lawson Health Research Institute:

Primary Outcome Measures:
  • Post-operative pain scores at admission to PACU [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    The primary outcome will be post-operative pain scores at I hour after arrival in PACU.


Secondary Outcome Measures:
  • Pain scores at 4 hours of arrival to PACU [ Time Frame: 4 hours ] [ Designated as safety issue: No ]
    patients will be assessed for pain scores at rest and movement after 4 hours of arrival to the recovery from the operating room


Other Outcome Measures:
  • first 24 pain scores [ Time Frame: Day1 ] [ Designated as safety issue: No ]
    Patients will be provided with a diary to document pain scores every 6 hourly thereafter until 24 hours after their time of arrival in PACU (time 0). Patients will be discharged home along with a data collection sheet for documenting pain scores, analgesic consumption and side effects at various time intervals.


Estimated Enrollment: 105
Study Start Date: June 2013
Estimated Study Completion Date: December 2015
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Group 1
Hamstrings block
Procedure: Hamstrings block
patients enrolled in the study will receive subsartorial saphenous nerve block in all the three groups. Patients in group 1 will receive perimuscular injections around the gracilis and semi-tendinosus muscles. The needle is redirected to the fascial plane between Sartorius and gracilis muscle after the sub-sartorial canal block where 7.5 ml of 0.5% ropivacaine is injected around the muscle. The needle is further advanced to the fascial planes between semimembranosus and semitendinosus and an additional 7.5 ml of 0.5% ropivacaine will be injected around the semitendinosus muscle. Following this a sham injection of 10mL of saline for the anterior division of obturator nerve will also be performed as in group 2 to ensure blinding.
Other Name: perimuscular injections
Active Comparator: Group 2
Obturator block
Procedure: Obturator block
Patients in group 2 will receive anterior division of obturator nerve block along with subsartorial canal block. After ensuring aseptic precautions, the saphenous nerve block is performed similar to that as in group 1. The anterior branch of obturator nerve will be visualised in the proximal thigh medial to femoral vessels between adductor longus and adductor brevis. A 22 gauge 90 mm PNS block needle will be inserted under ultrasound guidance to reach the anterior division of obturator nerve confirmed with neurostimulation followed by injection of 10 ml of 0.5% ropivacaine around the nerve. This group will receive sham injection of 15mL of saline around semitendinosus and semimembranosus as in group 1
Other Name: anterior division obturator nerve block
Sham Comparator: Group 3
Control group
Procedure: Control group
The patients in group 3 will form the control group. After performance of the subsartorial saphenous nerve block, patients in group 3 will receive sham injections of saline for the obturator nerve block and the hamstrings block (perimuscular injections).
Other Name: saline group

Detailed Description:

Performance of arthroscopic knee repairs on day care basis necessitates adequate post-operative analgesia for successful home discharge since post-operative pain is known to be the commonest cause of unanticipated readmissions of day care patients. Early return to activity is also crucial to ensure adequate surgical outcomes. Anterior cruciate ligament (ACL) repair is commonly performed by arthroscopic approach with an ipsilateral hamstring-gracilis graft. This has shown to be superior to patellar tendon grafts with regards to pain and functional outcomes after surgery. Postoperative pain from the graft donor site and anterior knee pain form the surgery can lead to decreased range of motion and poor rehabilitation. A variety of regional anesthetic techniques are being tried for out-patient knee surgery like spinal adjuvants; intra and peri-articular injection, single injection and continuous blocks of the femoral and sciatic nerves, oral pills and cryoanalgesia. Opioid based analgesia with or without co-analgesics is not suited for dynamic pain relief since Aα and Aδ nerve fibres that carry pain are poorly inhibited by opioids while effectively inhibited by local anesthetics. Multimodal analgesic regimens work well for ambulatory surgeries especially when combined with regional analgesic techniques. Regional techniques decrease opioid consumption and hence opioid related side effects. Intra and peri-articular injections have a short duration of action compared to nerve blocks apart from the concerns of chondrotoxicity of intra-articular local anesthetics. Although femoral- and sciatic nerve blocks provide adequate analgesia, the weakness of the quadriceps and hamstrings can prevent early rehabilitative efforts and also pose a risk for patient falls following home discharge. Hence, novel regional techniques of analgesia like blocking the infrapatellar branch of saphenous nerve, graft site injections of local anesthetics through the arthroscopic sleeve and single injection adductor canal block have been tried. Isolated sensory block of the surgical and graft site without motor block is the Holy Grail in search for these ambulatory patients.

Saphenous nerve, the terminal branch of femoral nerve supplies the majority of the knee joint. The femoral nerve exits the adductor canal and gives the terminal branch of saphenous nerve which lies between the Sartorius muscle and femoral artery in the sub-sartorial canal. Subsartorial canal block has been successfully utilized for forefoot surgery and knee arthroplasty but this has not been evaluated for ACL repairs. Saphenous nerve can be successfully blocked in the subsartorial canal without the risks of leg weakness but this alone is insufficient to provide analgesia to the graft donor site which is usually the gracilis tendon and the hamstrings tendon. Depositions of local anesthetics around the harvested muscle or blockade of the nerve supplying it are attractive strategies to decrease donor site pain but have not been explored for this purpose in a randomized fashion. The investigators hypothesize that the combination of any of the above two techniques to decrease donor site pain along with subsartorial saphenous nerve block can provide adequate analgesia in these patients. The anterior branch of the obturator nerve needs to be blocked since it supplies the gracilis muscle. To decrease the donor site pain, the saphenous nerve block can be combined with block of the anterior branch of obturator nerve. Alternatively, the saphenous nerve block can be combined with deposition of local anesthetic around the graft donor muscles. The extent to which the two techniques benefit the patients in terms of overall analgesia and the graft site analgesia has not been evaluated. With this background, the investigators want to compare the analgesic efficacy of subsartorial saphenous nerve block with either perihamstrings infiltration or blockade of the anterior division of obturator nerve in patients undergoing ACL reconstruction with ipsilateral autograft from gracilis and hamstring muscles.

  Eligibility

Ages Eligible for Study:   16 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Male and females of 16-85years of age, scheduled to undergo anterior cruciate ligament repair with ipsilateral hamstrings graft.
  2. ASA Class I-III

Exclusion Criteria:

  1. ASA 4
  2. Revision surgery
  3. Graft harvest from the contralateral hamstrings or allograft
  4. Narcotic dependent (opioid intake more than 3 months) or any chronic pain conditions
  5. Patients with associated significant cardiac and respiratory disease
  6. Patients with coexisting hematological disorder or with deranged coagulation parameters.
  7. Patients with pre-existing major organ dysfunction such as hepatic and renal failure.
  8. Psychiatric illnesses
  9. Emergency surgery
  10. Lack of informed consent.
  11. Allergy to any of the drugs used in the study
  12. Preoperative neurological deficits
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01868282

Contacts
Contact: Sugantha Ganapathy, FRCPC +15196858500 ext 35115 Sugantha.Ganapathy@lhsc.on.ca
Contact: Rakesh V Sondekoppam, MD 5196397585 rakesh6282@gmail.com

Locations
Canada, Ontario
University Hospital, London Health Sciences Center, Not yet recruiting
London, Ontario, Canada, N6A 5A5
Contact: Sugantha Ganapathy, FRCPC    5196858500 ext 35115    Sugantha.Ganapathy@lhsc.on.ca   
Principal Investigator: Sugantha Ganapathy, FRCPC         
Sub-Investigator: Rakesh Sondekoppam Vijayashankar, MD         
Sub-Investigator: Vishal Uppal, FRCA         
Sub-Investigator: Jonathan Brookes, FRCA         
Sub-Investigator: Robert Giffin, FRCSC         
Sub-Investigator: David Litchfield, FRCSC         
Sub-Investigator: Ravi Rastogi, MSc         
Sponsors and Collaborators
Lawson Health Research Institute
Investigators
Principal Investigator: Sugantha Ganapathy, FRCPC London Health sciences Center, Western University, London, Ontario, Canada; N6A5A5
  More Information

Publications:
Responsible Party: Sugantha Ganapathy, Principal Investigator, Lawson Health Research Institute
ClinicalTrials.gov Identifier: NCT01868282     History of Changes
Other Study ID Numbers: 103681
Study First Received: April 26, 2013
Last Updated: May 30, 2013
Health Authority: Canada: Ethics Review Committee

Keywords provided by Lawson Health Research Institute:
anterior cruciate ligament repair, Obturator nerve block, Hamstrings graft, Ropivacaine,
Postoperative pain

Additional relevant MeSH terms:
Ropivacaine
Anesthetics, Local
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
Sensory System Agents
Peripheral Nervous System Agents
Central Nervous System Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on April 22, 2014