Bone Strength After Spinal Cord Injury
After a traumatic spinal cord injury, a severe bone loss in the paralyzed extremities is observed. This leads to a osteoporosis which is connected to a high fracture risk.
To compare the two measurement methods DEXA and pQCT concerning optimal diagnostics and assessment of fracture risk in subjects with spinal cord injury.
250 women and 250 men (age≥18, any AIS-classification) with an acute or chronic spinal cord injury will be recruited for this study. For a reference group, 500 able-bodied persons will be measured analogously.
Using DEXA-Osteodensitometry, bone parameters of the lumbar vertebral column, proximal femur, distal radius, distal tibia and knee area will be assessed. Additionally, geometric bone parameters of the tibia will be measured by using pQCT. All measurements will be done unilaterally. For the assessment of potential risk factors for reduced bone stiffness after spinal cord injury a questionnaire will be used.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Impact of Spinal Cord Injury on Bone Strength in Paralysed Extremities.|
- Bone parameters [ Time Frame: just one timepoint ] [ Designated as safety issue: No ]Measurement of the extremities with DEXA and pQCT
- Fractures [ Time Frame: just one timepoint (questionnaire) ] [ Designated as safety issue: No ]Number of fractures since SCI
|Study Start Date:||October 2010|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Spinal Cord Injury
Persons with spinal cord injury Osteodensitometry DXA pQCT
Reference population (able-bodied) Osteodensitometry DXA pQCT
|Nottwil, Lucerne, Switzerland, 6207|
|Contact: Angela Frotzler, PhD +41419395561 email@example.com|
|Principal Investigator: Angela Frotzler, PhD|
|Principal Investigator:||Angela Frotzler, PhD||Swiss Paraplegic Centre Nottwil|