Dance and Huntington Disease

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified March 2013 by Institut National de la Santé Et de la Recherche Médicale, France
Sponsor:
Information provided by (Responsible Party):
Institut National de la Santé Et de la Recherche Médicale, France
ClinicalTrials.gov Identifier:
NCT01842919
First received: April 3, 2013
Last updated: April 25, 2013
Last verified: March 2013
  Purpose

In this project investigators will evaluate the benefits of contemporary dance training using a comprehensive test battery combining standard neuropsychological batteries, psychological questionnaires on emotion, empathy and quality of life, structural magnet-resonance tomography (MRI), as well as psychophysical tests on movement recognition and agency, the sense of being in control of one's own movement.

For 10 years now two experienced dancer‐choreographers lead dance workshops for people with Huntington's Disease (HD) and their family and caregivers in Paris. This project will evaluate objectively the effects these workshops have, by assessing a new group of 18 patients and their partners and caregivers before and after 8 month of weekly dance training.

People with HD are troubled by involuntary movements, of which they are however not accurately aware, but moreover they become impaired at recognising instrumental actions in others. It is well known that observing somebody else's action and executing the same action rest on a common neural network. This might mean that improving one's own action execution can improve the observation and understanding of others' actions in turn. Here, investigators will investigate both the impact the movement impairments caused by HD might have on patients themselves as well as on their partners and caregivers, as a consequence of the fact that own and other action representations are shared. After 8 months of contemporary dance training, both groups will be tested again, in order to establish if both action execution (self) and perception (in others) have improved.

Other recent psychophysics and brain imaging experiments have demonstrated how the sense of agency is composed from external cues (for example sound) of the consequences of movements, and from internal sensorimotor information that result from the action plan. Importantly, in HD the latter input might be impaired, but this has never been systematically tested. Making use of a psychophysics paradigm disentangling the two cues to agency investigators first monitor the sense of their own movement in HD, and further assess the changes in agency and in the role of these cues to agency after eight months of contemporary dance practice.

Finally investigators will monitor the structural brain changes accompanying this progress, comparing the brain before and after regular dance practice and correlating action recognition psychophysics measures of agency with these changes.

In sum, this project has a double impact. Firstly it will scientifically evaluate the impact of dance on the normal but especially the brain affected by a neurodegenerative disease that causes movement impairments, and establish its effect on behaviour and wellbeing. Secondly it will evaluate in patient partners and caregivers how they represent the patients' as well as their own movements and how this changes with dance practice.


Condition Intervention
Huntington Disease
Other: Kinesthetics tests
Other: Psychological questionnaires
Other: structural Magnetic ResonanceImaging (MRI)

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label

Resource links provided by NLM:


Further study details as provided by Institut National de la Santé Et de la Recherche Médicale, France:

Primary Outcome Measures:
  • Detection score [ Time Frame: Day 1 ] [ Designated as safety issue: No ]

    The subject performs movements imposed which are recorded by sensors in the form of bright spots.

    It shows the participant of "bright spots" of himself or of another subject of the same sex and must indicate whether of himself or another person.

    The number of correct answers is calculated and subtracted from the numbers of false positives.


  • Detection score [ Time Frame: 9th month ] [ Designated as safety issue: No ]

    The subject performs movements imposed which are recorded by sensors in the form of bright spots.

    It shows the participant of "bright spots" of himself or of another subject of the same sex and must indicate whether of himself or another person.

    The number of correct answers is calculated and subtracted from the numbers of false positives.

    The number of correct answers is calculated and subtracted from the numbers of false positives.



Estimated Enrollment: 62
Study Start Date: May 2013
Estimated Primary Completion Date: February 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Huntington patient
This group will perform Magnetic Resonance Imaging (MRI), kinesthetic test and psychological questionnaires before and after 8 months of dance lessons
Other: Kinesthetics tests Other: Psychological questionnaires Other: structural Magnetic ResonanceImaging (MRI)
Assisting Person
This group will perform MRI, kinesthetic test and psychological questionnaires before and after 8 months of dance lessons
Other: Kinesthetics tests Other: Psychological questionnaires Other: structural Magnetic ResonanceImaging (MRI)
Pilot subject
Healthy volunteers to set up the kinesthetic test
Other: Kinesthetics tests

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Huntington patient

  • Patients with Huntington's disease (documented by a genetic test.)
  • Ability and intention to follow the dance workshop of the association Micadanse once a week for 8 months (Total Functional Capacity score (TFC) > 10).
  • Have an assisting person who also lends him/herself to the protocol.
  • Showing no indications against to the achievement of MRI.

Assisting person:

  • No history of neurological or psychiatric disorders.
  • Showing no indications against to the achievement of MRI.

Exclusion Criteria:

  • Have already taken dance lessons.
  • Neurological or psychiatric history.
  • Inability to achieve MRI
  • History of significant head injury
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: Institut National de la Santé Et de la Recherche Médicale, France
ClinicalTrials.gov Identifier: NCT01842919     History of Changes
Other Study ID Numbers: C12-64, 2012-A01669-34
Study First Received: April 3, 2013
Last Updated: April 25, 2013
Health Authority: France: Agence Nationale de Sécurité du Médicament et des produits de santé

Additional relevant MeSH terms:
Chorea
Huntington Disease
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Cognition Disorders
Delirium, Dementia, Amnestic, Cognitive Disorders
Dementia
Dyskinesias
Genetic Diseases, Inborn
Heredodegenerative Disorders, Nervous System
Mental Disorders
Movement Disorders
Nervous System Diseases
Neurodegenerative Diseases

ClinicalTrials.gov processed this record on October 20, 2014