Study on Ocular Choroidal Thickness and Ocular Blood Flow in Glaucoma Patients
The choroid is one of the human body's most vascularized tissues. The choroidal tissue is mainly supplied by the short ciliary arteries, which are also the arteries responsible for most of the arterial vascularization of the optic nerve head. As this is the primary location where the majority of the glaucomatous neuron-related injury is thought to occur, the hypothesis remains as to whether a dysregulation in the vascular component of the choroidal tissue can be of significance in glaucoma pathogenesis. New technological advances in glaucoma imaging techniques, namely the enhanced depth imaging in optical coherent tomography (OCT) have recently allowed a non-invasive, non contact method for assessing the choroidal thickness.
By combining these new features with the existing methods for ocular blood flow analysis, including color Doppler Imaging, we try to determine if a correlation exists between the choroidal thickness and the blood flow of the ciliary arteries in glaucoma patients.
Open Angle Glaucoma
Normal Tension Glaucoma
|Study Design:||Time Perspective: Prospective|
|Official Title:||Correlation Between Submacular and Peripapillary Choroidal Tissue and Ocular Blood Flow in Glaucoma Patients|
- Choroidal thickness correlation with short ciliary arteries blood flow velocities [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 2 hours ] [ Designated as safety issue: No ]
|Study Start Date:||February 2013|
|Estimated Study Completion Date:||October 2013|
|Estimated Primary Completion Date:||October 2013 (Final data collection date for primary outcome measure)|
Healthy volunteers with no family history of glaucoma, an increased or asymmetrical cup/disc ratio or any other optic disc structural change (notching, disc hemorrhage) or an intraocular pressure (IOP) above 21 mmHg that could suggest possible glaucoma suspects.
Primary open-angle glaucoma
Patients with a characteristic optic disc damage (based on cup/disc ratio, thinning of neuroretinal rim, notching, disk hemorrhages, etc.) and visual field defects, with at least one measurement of IOP of >21 mmHg required
Normal Tension Glaucoma
Patients with a characteristic optic disc damage (based on cup/disc ratio, thinning of neuroretinal rim, notching, disk hemorrhages, etc.) and visual field defects, with at maximum recorded IOP of < 21 mmHg
- Visual field testing will be performed.
- Structural damage will be documented by a retinal nerve fiber layer analysis (through OCT)
- High Definition OCT imaging of the submacular and peripapillary choroidal thickness will be performed.
- Color Doppler Imaging of the retrobulbar vessels will be performed, with analysis of the Doppler waveform (peak systolic, end diastolic velocities and resistivity index)
|Leuven, Vlaams-Brabant, Belgium, 3000 Leuven|
|Contact: Luis Pinto, MD, PhD firstname.lastname@example.org|
|Principal Investigator: Ingeborg Stalmans, MD, PhD|