Trial record 20 of 347 for:    Open Studies | "Duke University" [Exact]

Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments (CameraCue)

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2014 by Duke University
Sponsor:
Information provided by (Responsible Party):
Duke University
ClinicalTrials.gov Identifier:
NCT01840111
First received: April 23, 2013
Last updated: April 2, 2014
Last verified: April 2014
  Purpose

The overarching goals of this proposal are to 1) identify the network of brain regions specifically activated by personal smoking environment cues and 2) to evaluate the effects of exposure to these cues on smoke self-administration and subjective reactivity. The results of this study will inform the development of novel and more efficacious cue-exposures therapies targeted at helping smokers quit smoking and will provide novel mechanism information regarding the influence of environmental context on drug taking.

The investigator hypothesizes that cue-exposure treatments (CETs), in which drug use is prevented during exposure to drug cues (e.g. lit cigarette) have been of limited efficacy in part because they have not included cues representative of the contexts in which drug use occurs. By demonstrating that context cues have a differential and robust influence on brain and behavioral responses, we will have provided a substantial basis for including such stimuli in the context of treatment. At the same time, we will have identified novel mechanisms by which such stimuli promote continued drug use and relapse.


Condition Intervention
Smoking
Healthy
Behavioral: Quit Smoking 6 hours
Behavioral: Quit Smoking 24 hours

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments

Resource links provided by NLM:


Further study details as provided by Duke University:

Primary Outcome Measures:
  • Signal Change in Functional Magnetic Resonance Imaging (fMRI) BOLD Signal between Personal Environment Pictures Relative to Standard Environment Pictures [ Time Frame: following 24 hours of smoking abstinence ] [ Designated as safety issue: No ]
    During fMRI scanning participants will view pictures of personal and standard smoking and non-smoking environments; and also pictures of smoking-related and non-smoking related objects


Estimated Enrollment: 120
Study Start Date: December 2012
Estimated Primary Completion Date: January 2015 (Final data collection date for primary outcome measure)
Intervention Details:
    Behavioral: Quit Smoking 6 hours
    participants will quit smoking 6 hours prior to the cue-exposure sessions
    Behavioral: Quit Smoking 24 hours
    participants will quit smoking 24 hours prior to the fMRI scan
  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • generally healthy
  • between the ages of 18 and 55
  • smoking an average of 5 cigarettes per day for at least one year
  • breath CO (carbon monoxide) level > 8 ppm (if ≤ 8 ppm, then NicAlert Strip > 2)
  • no interest in quitting smoking for the duration of time required for the experiment
  • right-handed as measured by a three-item scale used in our laboratory
  • ability to identify 4 personal smoking and 4 personal non-smoking places

Exclusion Criteria:

  • inability to attend all required experimental sessions
  • significant health problems
  • use of psychoactive medications
  • use of smokeless tobacco
  • current alcohol or drug abuse
  • use of illegal drugs as measured by urine drug screen
  • current use of nicotine replacement therapy or other smoking cessation treatment
  • presence of conditions that would make MRI unsafe (e.g., pacemaker)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01840111

Locations
United States, North Carolina
Duke University Medical Center Recruiting
Durham, North Carolina, United States, 27705
Contact: Nicole Kaiser, BA       nicole.kaiser@dm.duke.edu   
Sponsors and Collaborators
Duke University
Investigators
Principal Investigator: Joseph McClernon, Ph.D Duke University
  More Information

No publications provided

Responsible Party: Duke University
ClinicalTrials.gov Identifier: NCT01840111     History of Changes
Other Study ID Numbers: Pro00033975
Study First Received: April 23, 2013
Last Updated: April 2, 2014
Health Authority: United States: Institutional Review Board

Keywords provided by Duke University:
smoking environment
cue-exposure
cigarettes
nicotine
fMRI

Additional relevant MeSH terms:
Smoking
Habits

ClinicalTrials.gov processed this record on July 28, 2014