Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft (NOAHS)
The purpose of the study is to examine if blood flow in the brain before coronary artery bypass graft surgery has an effect on depression after surgery.
The main hypothesis of the study states that pre-surgical blood flow in the brain will be an independent risk factor for depression after surgery after adjusting for other risk factors such as gender, pre-CABG depression, social support, medical comorbidity burden, socioeconomic status, and neuroticism.
Coronary Artery Disease
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Intracranial Atherosclerosis and Predictors of Post-CABG Depression|
- Pre-surgical intracranial atherosclerosis as measured by transcranial doppler ultrasound relative to depressive symptoms post-surgically as measured by DISH. [ Time Frame: 12 months ] [ Designated as safety issue: No ]
- Examine neurocognitive function relative to post-CABG depression through a series of neurocognitive tests. [ Time Frame: 12 months ] [ Designated as safety issue: No ]Neurocognitive tests are aimed at evaluating memory, processing speed, and global cognition.
|Study Start Date:||September 2012|
|Estimated Primary Completion Date:||February 2015 (Final data collection date for primary outcome measure)|
|United States, Connecticut|
|Yale University School of Medicine||Recruiting|
|New Haven, Connecticut, United States, 06510|
|Contact: Hochang B Lee, MD 203-785-2618|
|Principal Investigator: Hochang B Lee, MD|
|United States, Maryland|
|The Johns Hopkins University||Terminated|
|Baltimore, Maryland, United States, 21218|