Diagnosis of Subclinical Urinary Tract Infections Using Advanced Microbiome Survey Techniques in High Risk Trauma Patients
The purpose of this study is to see if the investigators can identify early those patients who are admitted to the hospital and have a urinary tract infection (UTI) or those patients that develop a UTI during their hospitalization.
Urinary Tract Infection
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Diagnosis of Subclinical Urinary Tract Infections Using Advanced Microbiome Survey Techniques in High Risk Trauma Patients|
- Identify of bacteria, genes and proteins that are highly predictive of UTI development [ Time Frame: Nine months ] [ Designated as safety issue: No ]To identify which bacteria, genes and proteins will be highly predictive of UTI development in geriatric trauma patients. We hypothesize that the combination of 16S rDNA and metaproteomics will identify the most informative biosignatures (species/genes/proteins) discerning UTI from asymptomatic bacteriuria.
- Biomarker candidates for UTIs recalcitrant to antibiotic treatment. [ Time Frame: Nine months ] [ Designated as safety issue: No ]
- Morbidity [ Time Frame: 9 months ] [ Designated as safety issue: No ]
- Mortality [ Time Frame: 9 months ] [ Designated as safety issue: Yes ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||March 2013|
|Estimated Study Completion Date:||May 2014|
|Primary Completion Date:||September 2013 (Final data collection date for primary outcome measure)|
Geriatric Traumatic Injury
Geriatric trauma pateints being admitted to Saint Marys Hosptial.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01834391
|United States, Minnesota|
|Mayo Clinic in Rochester|
|Rochester, Minnesota, United States, 55905|
|Principal Investigator:||Martin Zielinski, MD||Mayo Clinic|