Non-invasive and Invasive Plaque Characterisation
The accuracy of coronary plaque characterization with Multi-slice computed tomography as compared to intravascular ultrasound and optical coherence tomography will be investigated in patients presenting with acute coronary syndrome without ST-elevation.
|Study Design:||Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||Coronary Artery Plaque Characterisation With Non-invasive Multi-Slice Computed Tomography and Invasive Intravascular Ultrasound and Optical Coherence Tomography in Patients With Acute Coronary Syndromes Without ST-segment Elevation|
- Accuracy of detection of thrombus with MSCT as compared to IVUS and OCT will be investigated. [ Time Frame: 24 hours ] [ Designated as safety issue: No ]All imaging methods will be performed in each patient. A 24 hour period is the maximum allowed time gap between MSCT and invasive imaging (OCT/IVUS).
- Accuracy of atherosclerotic plaque characterisation with MSCT as compared to IVUS and OCT will be investigated. [ Time Frame: 24 hours ] [ Designated as safety issue: No ]A maximum interval of 24 hours between MSCT and IVUS/OCT is allowed in this study.
|Study Start Date:||June 2011|
|Estimated Primary Completion Date:||July 2013 (Final data collection date for primary outcome measure)|
There is only one arm in this study. All patients undergo MSCT, IVUS and OCT.
All patients undergo non-invasive (MSCT) and invasive (IVUS, OCT) imaging
Please refer to this study by its ClinicalTrials.gov identifier: NCT01833338
|Contact: Wouter G Wieringa, MD||+31 50 firstname.lastname@example.org|
|Contact: Chris PH Lexis, MD|
|University Medical Center Groningen, Departments of Cardiology and Radiology||Recruiting|
|Groningen, Netherlands, 9700 RB|
|Contact: Gabija Pundziute, MD, PhD +31 50 3619477 email@example.com|
|Principal Investigator: Gabija Pundziute, MD, PhD|
|Principal Investigator: Tineke Willems, MD,PhD|
|Sub-Investigator: Wouter G Wieringa, MD|
|Sub-Investigator: Chris PH Lexis, MD|
|Principal Investigator:||Gabija Pundziute, MD, PhD||Department of Cardiology|
|Principal Investigator:||Tineke Willems, MD, PhD||Department of Radiology|