Trial record 5 of 67 for:    Open Studies | "Food Hypersensitivity"

Molecular Basis of Food Allergy

This study is currently recruiting participants.
Verified October 2013 by Children's Hospital of Philadelphia
Sponsor:
Collaborators:
University of Pennsylvania
Information provided by (Responsible Party):
Jonathan Spergel, Children's Hospital of Philadelphia
ClinicalTrials.gov Identifier:
NCT01832324
First received: April 12, 2013
Last updated: October 21, 2013
Last verified: October 2013
  Purpose

The Study examines the molecular basis of food allergy. It explores the interaction between T cells, InKT cells and cytokines in the development of food allergy. The study also explores these factors in development of tolerance "outgrowing" food allergy. It will also explore the genetic factors that lead to the development of food allergy.


Condition
Food Allergy
Eosinophilic Esophagitis
Food Protein Induced Enterocolitis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Molecular Basis of Food Allergy

Resource links provided by NLM:


Further study details as provided by Children's Hospital of Philadelphia:

Primary Outcome Measures:
  • T cell Phenotype in Patients with Food Allergy [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

DNA, sera and PBMC


Estimated Enrollment: 1000
Study Start Date: January 2011
Estimated Primary Completion Date: December 2018 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   4 Months to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Food Allergy (Both IgE and Non-IgE Mediated) Atopic Controls Healthy controls

Criteria

Inclusion Criteria:

  • Food Allergy

    • Eosinophilic Esophagitis confirmed on upper endoscopy and biopsy per current consensus guidelines
    • Food Protein Induced Enterocolitis

Exclusion Criteria:

  • Refusal to Sign Consents -- Conditions that do not allow for blood draws
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01832324

Contacts
Contact: Kathy Pinzone pinzone@email.chop.edu

Locations
United States, Pennsylvania
The Children's Hospital of Philadelphia Recruiting
Philadephia, Pennsylvania, United States, 19104
Contact: Courtney Rooney       rooneyc@email.chop.edu   
Principal Investigator: Jonathan M Spergel, MD, PhD         
Sponsors and Collaborators
Children's Hospital of Philadelphia
University of Pennsylvania
Investigators
Principal Investigator: Jonathan M Spergel, MD, PhD Children's Hospital of Philadelphia
  More Information

No publications provided

Responsible Party: Jonathan Spergel, Professor of Pediatrics, Children's Hospital of Philadelphia
ClinicalTrials.gov Identifier: NCT01832324     History of Changes
Other Study ID Numbers: CHOP IRB 005998
Study First Received: April 12, 2013
Last Updated: October 21, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by Children's Hospital of Philadelphia:
Food Allergy
Eosinophilic Esophagitis
Food Protein Induced Enterocolitis
iNKT Cells
T cells

Additional relevant MeSH terms:
Food Hypersensitivity
Hypersensitivity
Enterocolitis
Esophagitis
Eosinophilic Esophagitis
Immune System Diseases
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
Intestinal Diseases
Esophageal Diseases
Hypersensitivity, Immediate
Eosinophilia
Leukocyte Disorders
Hematologic Diseases

ClinicalTrials.gov processed this record on April 15, 2014