Manipulation of Dietary Protein and the Anabolic Response (PRO-ADAPT)

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Maastricht University Medical Center
ClinicalTrials.gov Identifier:
NCT01820975
First received: March 18, 2013
Last updated: April 10, 2014
Last verified: April 2014
  Purpose

In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.


Condition Intervention
Focus: Anabolic Response to Food Intake in Young Individuals.
Condition Relevance: Skeletal Muscle Health, Sarcopenia.
Dietary Supplement: High protein meals

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: The Manipulation of Dietary Protein Intake on the Anabolic Response in Healthy Young Men

Resource links provided by NLM:


Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • Muscle protein fractional synthetic rate following protein ingestion [ Time Frame: 3 hours ] [ Designated as safety issue: No ]
    The ability of the muscle to synthesise new proteins will be assessed over a 3 h period following protein ingestion and will be compared between groups. This only occurs on one occasion.


Estimated Enrollment: 28
Study Start Date: April 2013
Estimated Study Completion Date: November 2014
Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: High protein intake
High protein intake: large bolus of protein in teh diet the day before testing
Dietary Supplement: High protein meals
N/A
Placebo Comparator: No protein intake
No protein in the diet the day before testing

  Eligibility

Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Males
  • Aged between 18-35 years
  • Healthy, recreationally active
  • BMI < 30 kg/m2

Exclusion Criteria:

  • Smoking
  • Allergies to milk proteins (whey or casein)
  • Vegetarians
  • Diagnosed GI tract diseases
  • Female
  • Arthritic conditions
  • A history of neuromuscular problems
  • Previous participation in amino acid tracer studies
  • Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01820975

Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: Luc JC van Loon, PhD Maastricht University
  More Information

No publications provided

Responsible Party: Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01820975     History of Changes
Other Study ID Numbers: METC 12-3-067
Study First Received: March 18, 2013
Last Updated: April 10, 2014
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Maastricht University Medical Center:
Muscle protein synthesis
Dietary protein

Additional relevant MeSH terms:
Sarcopenia
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Atrophy
Pathological Conditions, Anatomical
Signs and Symptoms

ClinicalTrials.gov processed this record on April 23, 2014