Predicting Cognitive and Emotional Health From Neurocircuitry Following TBI
Abnormalities in structural and functional connectivity between brain regions have been suggested as putative biomarkers of mild traumatic brain injury (TBI) and significant contributors to neuropsychological functioning and injury outcome. The purpose of this study is to use two advanced magnetic resonance imaging (MRI) techniques called diffusion-weighted imaging (DWI) and resting state functional MRI to compare structural and functional connectivity between individuals with documented mild TBI and healthy controls. To evaluate the significance of structural and functional connectivity for behavior, the brain imaging data will then be related to measures of cognition and emotion. Over a 4-year period, 150 adults with documented mild TBI and 30 healthy controls will participate in the study.
The study will investigate the following questions and hypotheses:
- Evaluate the DWI metric fractional anisotropy (FA) as a measure of white matter integrity across multiple stages of recovery following mild TBI relative to healthy controls. It is hypothesized that mild TBI will be associated with greater white matter abnormalities than healthy controls.
- It is hypothesized that there will be a relationship between FA, cognition and emotion as a function of the injury.
- It is hypothesized that functional connectivity will be related to FA.
Traumatic Brain Injury
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||A Model for Predicting Cognitive and Emotional Health From Structural and Functional Neurocircuitry Following Traumatic Brain Injury|
- Diffusion Weighted Imaging Metric: fractional anisotropy (FA) [ Time Frame: Measured on the day of the MRI scan ] [ Designated as safety issue: No ]
|Study Start Date:||February 2013|
|Estimated Primary Completion Date:||March 2017 (Final data collection date for primary outcome measure)|
30 individuals who will be tested at two weeks post-TBI; 30 individuals who will be tested at one month post-TBI; 30 individuals who will be tested at three months post-TBI; 30 individuals who will be tested at six months post-TBI; 30 individuals who will be tested at 12 months post-TBI.
30 healthy individuals with no history of TBI
|Contact: Maia Kipmanfirstname.lastname@example.org|
|United States, Massachusetts|
|Belmont, Massachusetts, United States, 02478|
|Contact: Maia Kipman 617-855-2239|
|Principal Investigator: William D Killgore, Ph.D.|
|Principal Investigator:||William D Killgore, Ph.D.||Mclean Hospital|