The Prognostic Assessment of Extubation in Aged Patients With Multiple Organ Dysfunction Syndrome

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2013 by Chinese PLA General Hospital
Sponsor:
Information provided by (Responsible Party):
Kun Xiao, Chinese PLA General Hospital
ClinicalTrials.gov Identifier:
NCT01802983
First received: February 27, 2013
Last updated: March 1, 2013
Last verified: February 2013
  Purpose

The multiple organ dysfunction syndrome (MODS) has remained the major factor contributing to prolongation of intensive and mortality. It is reported that the mortality rates have varied between 20% and 100%, depending on number, severity, duration, type and combination, and definition of dysfunction. In our study, the investigators explore some comprehensive treatment technology to improved outcomes of MODS patients.


Condition
Multiple Organ Dysfunction Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Key Technology Research of the Comprehensive Treatment of Multiple Organ Dysfunction Syndrome

Further study details as provided by Chinese PLA General Hospital:

Primary Outcome Measures:
  • the prognostic assessment of aged patients with MODS [ Time Frame: 28 days ] [ Designated as safety issue: No ]
    According to the outcomes of 28-day,all the enrolled patients were divided into survival group and death group, clinical datum of which were collected and analysed. And then these prognosis were evaluated with the current scoring systems [(Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ, APACHE Ⅲ), Sample Acute Physiological score(SAPSⅡ), Multiple Organ Dysfunction score(MODS)], the predictive power of which were compared by receiver operating characteristic(ROC) curve. Finally, a binary logistic regression analysis was performed to evaluate the concerning prognostic factors of MODSE.


Estimated Enrollment: 1
Study Start Date: January 2009
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   60 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

All subjects were selected from among inpatients who were hospitalized between Jan 2009 and May 2013 in the Respiratory Intensive Care Unit(RICU),Surgical Intensive Care Unit(SICU) and Emergency Intensive Care Unit(EICU).

Criteria

Inclusion Criteria:

  • age > 60 years old;
  • presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention;
  • have trachea intubation after admitting to intensive care unit within 24 hours.

Exclusion Criteria:

  • end stage multiple organ failure.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01802983

Contacts
Contact: Xiao Kun, doctor +8613716608331 xiaok301@163.com

Locations
China, Beijing
Chinese PLA General Hospital Recruiting
Beijing, Beijing, China, 100853
Contact: Xie Lixin, doctor    +86 010 55499130    xielx@263.net   
Sponsors and Collaborators
Chinese PLA General Hospital
  More Information

No publications provided by Chinese PLA General Hospital

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Kun Xiao, Key Technology Research of the comprehensive treatment of Multiple organ dysfunction syndrome, Chinese PLA General Hospital
ClinicalTrials.gov Identifier: NCT01802983     History of Changes
Other Study ID Numbers: 2013670808
Study First Received: February 27, 2013
Last Updated: March 1, 2013
Health Authority: China: Ethics Committee

Keywords provided by Chinese PLA General Hospital:
Aged
Multiple organ failure
Extubation
Prognosis
MODS
invasive mechanical ventilation

Additional relevant MeSH terms:
Multiple Organ Failure
Shock
Pathologic Processes

ClinicalTrials.gov processed this record on August 20, 2014