Enhancing Written Communication in Persons With Aphasia
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Purpose
The purpose of this study is to evaluate whether a computerized speech-language treatment delivered by a virtual therapist (Oral Reading for Language in Aphasia (ORLA) + Writing) results in improved written communication skills of study participants with aphasia (i.e., difficulty with the comprehension and expression of spoken and written language).
| Condition | Intervention |
|---|---|
|
Aphasia Stroke |
Behavioral: ORLA Behavioral: ORLA + Writing |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Outcomes Assessor) Primary Purpose: Treatment |
| Official Title: | Enhancing Written Communication in Persons With Aphasia: A Clinical Trial |
- Writing Score on the Western Aphasia Battery-Revised (WAB-R) from pre-treatment to post-treatment [ Time Frame: Change from baseline to 6 weeks ] [ Designated as safety issue: No ]
- Western Aphasia Battery-Revised Aphasia Quotient (WAB-R AQ) [ Time Frame: Change from baseline to 6 weeks ] [ Designated as safety issue: No ]
- Written Language Sample Analysis [ Time Frame: Change from baseline to 6 weeks ] [ Designated as safety issue: No ]Written responses on the Picture Description task of the Western Aphasia Battery-Revised and on a written picture-sequenced story retelling task will be scored for Correct Information Units
- Communicative Effectiveness Index (CETI) [ Time Frame: Change from baseline to 6 weeks ] [ Designated as safety issue: No ]
- ASHA Quality of Communication Life Scale (QCL) [ Time Frame: Change from baseline to 6 weeks ] [ Designated as safety issue: No ]
- Community Integration Questionnaire (CIQ) [ Time Frame: Change from baseline to 6 weeks ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 50 |
| Study Start Date: | February 2013 |
| Estimated Study Completion Date: | September 2015 |
| Estimated Primary Completion Date: | September 2015 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: ORLA
Practice on ORLA (Oral Reading for Language in Aphasia), a computer-based virtual therapy system, for 90 minutes per day, 6 days per week for 6 weeks.
|
Behavioral: ORLA
Practice on ORLA (Oral Reading for Language in Aphasia), a computer-based virtual therapy system.
|
|
Experimental: ORLA + Writing
Practice on "ORLA + writing" computer program, 90 minutes per day, 6 days per week, for 6 weeks.
|
Behavioral: ORLA + Writing
Treatment includes writing of sentences in combination with ORLA
|
Detailed Description:
Stroke is the third leading cause of death and the most common cause of disability in the United States. According to the American Stroke Association, the prevalence of stroke in the U.S. is approximately 4.8 million with approximately 700,000 additional strokes occurring annually. Approximately 150,000 to 250,000 stroke survivors becoming severely and permanently disabled each year. A common neurological deficit among stroke survivors, and thus a substantial contributor to post-stroke disability, is aphasia. The loss of, or difficulty with language is extremely debilitating.
Adequate written communication skills may be one of the barriers that has prevented individuals with aphasia from returning to work. Writing skills are also important for participation in social roles, such as household management, civic activities, or recreational activities with friends. Individuals with aphasia struggle to compose written documents such as personal letters, memos and reports. Furthermore, society's increased reliance on written forms of communication including email correspondence, instant messaging, texting, Twitter, and social networking sites such as Facebook, exacerbate the challenge that individuals with aphasia have in connecting with others, reestablishing and redefining their social roles and accomplishing their life-participation goals.
Computer-directed treatment offers a practical alternative to one-on-one traditional treatment provided by a clinician and may be a cost-effective way of extending therapy beyond the hospital and clinic to meet the needs of the growing numbers of individuals with chronic aphasia and to help them reintegrate into the community and workforce. This project evaluates the efficacy of a theoretically-motivated writing program that has been integrated with novel computer-based virtual therapy systems and that can be provided intensively to individuals with chronic aphasia.
Eligibility| Ages Eligible for Study: | 18 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- men or women with diagnosis of an aphasia subsequent to a left-hemisphere infarct(s) that is confirmed by CT scan or MRI
- an Aphasia Quotient score on the Western Aphasia Battery of 50-85.
- 6 months post injury
- premorbidly right handed, determined by Edinburgh Handedness Inventory
- completed at least an eighth grade education
- premorbidly literate in English
- visual acuity may be corrected but must be sufficient for reading visual stimuli on computer screen
- auditory acuity may be aided but must be sufficient for hearing auditory stimuli in ORLA program
Exclusion Criteria:
- any other neurological condition (other than cerebral vascular disease) that could potentially affect cognition or speech, such as Parkinson's Disease, Alzheimer's Dementia, traumatic brain injury.
- any significant psychiatric history prior to the stroke, such as severe major depression or psychotic disorder requiring hospitalization; subjects with mood disorders who are currently stable on treatment will be considered.
active substance abuse.
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Contacts and Locations| Contact: Leora R Cherney, Ph.D. | 312-238-1117 | lcherney@ric.org |
| Contact: Jaime B. Lee, M.S. | 312-238-6163 | jlee@ric.org |
| United States, Illinois | |
| Center for Aphasia Research and Treatment, Rehabilitation Institute of Chicago | Recruiting |
| Chicago, Illinois, United States, 60611 | |
| Contact: Leora R Cherney, Ph.D. 312-238-1117 lcherney@ric.org | |
| Contact: Jaime B Lee, M.S. 312-238-6163 jlee@ric.org | |
More Information
No publications provided
| Responsible Party: | Leora Cherney, Senior Research Scientist, Rehabilitation Institute of Chicago |
| ClinicalTrials.gov Identifier: | NCT01790880 History of Changes |
| Other Study ID Numbers: | 74374 |
| Study First Received: | February 11, 2013 |
| Last Updated: | February 11, 2013 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Rehabilitation Institute of Chicago:
|
Aphasia Stroke Speech Rehabilitation |
Additional relevant MeSH terms:
|
Aphasia Stroke Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations |
Nervous System Diseases Signs and Symptoms Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Vascular Diseases Cardiovascular Diseases |
ClinicalTrials.gov processed this record on May 22, 2013