Trial record 2 of 235 for:    Open Studies | "Aging"

Effects of Exercise Intervention on Aging-related Motor Decline (EIAMD)

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by Department of Veterans Affairs
Sponsor:
Information provided by (Responsible Party):
Department of Veterans Affairs
ClinicalTrials.gov Identifier:
NCT01787292
First received: February 5, 2013
Last updated: March 25, 2014
Last verified: March 2014
  Purpose

The purpose of this research study is to test whether differing levels of physical fitness affects patterns of motor dexterity and brain activity that have been shown to differ due to aging. Testing will take place at the Atlanta VA Medical Center and at Emory University.

Participants will be healthy adults within the target age range of 60-85 for the study. The study will require multiple visits over 15 months. There will be about 64 people volunteering for this study.


Condition Intervention
Aging
Exercise
Behavioral: Coordination training
Behavioral: Short Term exercise - supervised
Behavioral: Long Term Exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Effects of Exercise Intervention on Aging-related Motor Decline (AGING)

Resource links provided by NLM:


Further study details as provided by Department of Veterans Affairs:

Primary Outcome Measures:
  • Motor Dexterity Score Improvement [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
    Motor dexterity will be improved with finger coordination training.


Secondary Outcome Measures:
  • Interhemispheric Inhibition Improvement after Exercise [ Time Frame: 12 Weeks ] [ Designated as safety issue: No ]
    Participants who exercise will evidence increased levels of interhemispheric inhibition as assessed by transcranial magnetic stimulation and functional magnetic resonance imaging.

  • Enhanced Interhemispheric Inhibition Improvement after Long Term Exercise [ Time Frame: 6 months ] [ Designated as safety issue: No ]
    Participants who exercise will evidence larger increases in interhemispheric inhibition as assessed by transcranial magnetic stimulation and functional magnetic resonance imaging after a six month, self-directed exercise intervention.


Estimated Enrollment: 40
Study Start Date: January 2013
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Motor coordination training
Finger movement coordination training using sequenced finger movements of varying pressure.
Behavioral: Coordination training
finger movement coordination training using sequenced finger movements of varying pressure.
Experimental: Exercise - cycling
3 bouts of 45 minutes weekly on a cycle ergometer. HR will be kept at 75% of age-related maximum
Behavioral: Short Term exercise - supervised
Supervised weekly exercise. 3 bouts of 45 minutes weekly on a cycle ergometer. HR will be kept at 75% of age-related maximum.
Active Comparator: Waiting period
12 week enrollment waiting period after which treatment arms will begin
Behavioral: Coordination training
finger movement coordination training using sequenced finger movements of varying pressure.
Behavioral: Short Term exercise - supervised
Supervised weekly exercise. 3 bouts of 45 minutes weekly on a cycle ergometer. HR will be kept at 75% of age-related maximum.
Behavioral: Long Term Exercise
6 month self-monitored training phase during which time participants will exercise according to prescribed regimen (cycling)
Experimental: Long-term exercise - cycling
6 month self-monitored training phase during which time participants will exercise according to prescribed regimen (cycling)
Behavioral: Long Term Exercise
6 month self-monitored training phase during which time participants will exercise according to prescribed regimen (cycling)

Detailed Description:

The U.S. Census reports over 14 million U.S. Veterans (>63%) are beyond mid-life (>55 years). Declines in upper extremity motor performance respective of strength and dexterity are well documented within this age cohor). Recent cross-sectional research has discovered that aging related motor deficits may be influenced by a loss of interhemispheric inhibition (IHI) between primary motor cortices. However, this loss may not be an inevitable consequence of aging. Work from previous VA OAA Predoctoral and CDA-1 awards have shown that aerobic fitness may serve to mitigate losses in interhemispheric inhibition assessed by both functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS). That is, individuals who are aerobically fit show higher levels of IHI and improved dexterity and reaction times.

In light of new evidence from our lab's recent cross-sectional studies, physical activity over the long term (at least 2-5 years) may serve to alter levels of IHI and improve motor performance in the upper extremity. Aerobic exercise may provide a mechanism (reduced loss of interhemispheric inhibition) that could serve to improve motor function, but the neural mechanism responsible for such effects remains unclear. Previous investigations of interhemispheric communication and exercise have been limited by nature of inquiry, as cross-sectional research cannot measure changes over time in participants. As such, it is currently unknown how exercise may directly affect levels of interhemispheric communication and motor performance.

Behavioral interventions (motor strength and coordination) have been shown to be effective in improving upper extremity motor performance in older adults, however the duration of these gains appear to be short-lived. After as little as a few weeks of detraining, motor strength and coordination in the upper extremity rapidly begins to return to pre-intervention levels. Evidence from exercise interventions assessing gait and locomotion have shown that exercise programs over a longer term (>6 months) are associated with improved proprioception, fewer falls and better balance. However, the comparison of outcomes of upper extremity function in elderly adults respective of exercise duration remains largely unexplored. In addition to comparing the effects of short-term exercise (3 months) versus behavioral training (3 months) on upper extremity function, the current proposal will evaluate if a longer-term (6 months) exercise program can maintain or enhance upper extremity function and associated levels of interhemispheric inhibition.

The current study proposes the next logical step in my line of research and directly investigates the effects of exercise in an intervention with sedentary older Veterans (50-80 years), a group most likely to exhibit aging-related motor deficits. We propose to enroll 40 Veterans into an upper extremity dexterity improvement program involving behavioral and exercise components. The behavioral intervention is a muscle coordination training previously shown to improve unimanual motor performance in older adults. The exercise intervention is a supervised group cycling regimen. The figure below shows the study design. Interhemispheric communication will be assessed with fMRI, and TMS.

  Eligibility

Ages Eligible for Study:   60 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Living persons between 60 and 85 years of age

Exclusion Criteria:

  • insulin dependent diabetes
  • participants completing vigorous exercise per week
  • participants whose profession requires vigorous physical labor
  • contraindication to magnetic resonance imaging
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01787292

Contacts
Contact: Keith McGregor, PhD (404) 321-6111 ext 6795 Keith.McGregor2@va.gov
Contact: Holly Hudson, BS (404) 321-6111 ext 7099 holly.hudson@va.gov

Locations
United States, Georgia
Atlanta VA Medical and Rehab Center, Decatur, GA Recruiting
Decatur, Georgia, United States, 30033
Contact: Keith McGregor, PhD    404-321-6111 ext 6795    Keith.McGregor2@va.gov   
Contact: Holly Hudson, BS    (404) 321-6111 ext 7099    holly.hudson@va.gov   
Principal Investigator: Keith McGregor, PhD         
Sponsors and Collaborators
Investigators
Principal Investigator: Keith McGregor, PhD Atlanta VA Medical and Rehab Center, Decatur, GA
  More Information

No publications provided

Responsible Party: Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT01787292     History of Changes
Other Study ID Numbers: E0956-W, 2012-060697
Study First Received: February 5, 2013
Last Updated: March 25, 2014
Health Authority: United States: Federal Government

Keywords provided by Department of Veterans Affairs:
Exercise
Magnetic Resonance Imaging
Transcranial Magnetic Stimulation
Aging

ClinicalTrials.gov processed this record on July 26, 2014