Changes in Mitochondrial Uncoupling Protein 2 (UCP2) Messenger RNA(mRNA) in Type 2 Diabetes (T2DM) Patients
Many patients with Diabetes find difficulties in achieving glycemic control. Hemoglobin A1c(HgBA1c) is used as a marker for glycemic control. UCP2 is affected by high glucose levels, high free fatty acids and high oxidative stress.
The investigators intend to learn about the changes in UCP2 along the process of reaching glycemic control.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Changes in UCP2 mRNA in T2DM Patients|
- Levels of gene expression for UCP2 (RQ) [ Time Frame: 6 months ] [ Designated as safety issue: No ]Checking UCP2 levels compared to HgBA1c
- Improved metabolic state [ Time Frame: 6 months ] [ Designated as safety issue: No ]Glycemic control (glucose level and HgA1c), levels of free reactive oxygen species (ROS) and non-esterified fatty acids (NEFAs).
Biospecimen Retention: Samples Without DNA
Whole blood for UCP2 mRNA
|Study Start Date:||January 2013|
|Estimated Study Completion Date:||January 2014|
|Estimated Primary Completion Date:||January 2014 (Final data collection date for primary outcome measure)|
Un balanced diabetic patients
Procedure: Blood withdrawal
This is the only intervention that is part of the study. A family physician or other physician will be responsible of the diabetic treatment (common treatment, e.g Metformin).
|Contact: Nachum Vaisman, MDemail@example.com|
|Tel Aviv Sourasky Medical Center||Recruiting|
|Tel-Aviv, Israel, 64239|
|Contact: Nachum Vaisman, MD 972-3-6974807 firstname.lastname@example.org|
|Principal Investigator: Nachum Vaisman, MD|