Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

MEVALONATE KINASE GENE MUTATIONS AND THEIR CLINICAL CORRELATIONS IN BEHÇET'S DISEASE

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Didem Arslan Tas, Cukurova University
ClinicalTrials.gov Identifier:
NCT01780363
First received: January 29, 2013
Last updated: NA
Last verified: January 2011
History: No changes posted
  Purpose

Background: Genetics is suggested to play a critical role in the development of Behçet's disease (BD). Shared phenotypic features requires an approach to the differential diagnosis from periodic febrile syndromes particularly from mevalonate kinase deficiency related diseases. We planned to study for evaluating the frequency of mutations and their clinical significance in mevalonate kinase gene in Turkish patients with Behçet's disease.


Condition
Behçet's Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Cukurova University:

Primary Outcome Measures:
  • Frequency of mevalonate kinase frequency in Behçet disease [ Time Frame: One year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Mevalonate kinase gene and clinical correlations in Behçet's disease [ Time Frame: One year ] [ Designated as safety issue: No ]

Study Start Date: January 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
controls
frequency of mevalonate kinase gene frequency
Behçet patients
frequency of mevalonate kinase gene mutations

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Turkish kindred

Criteria

Inclusion Criteria:

  • Behçet patients

Exclusion Criteria:

  • Diagnosis of periodic fever syndromes
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01780363

Locations
Turkey
Cukurova University
Adana, Turkey, 01330
Didem Arslan Tas
Adana, Turkey, 01330
Sponsors and Collaborators
Cukurova University
  More Information

No publications provided

Responsible Party: Didem Arslan Tas, MD, Cukurova University
ClinicalTrials.gov Identifier: NCT01780363     History of Changes
Other Study ID Numbers: BH-MVK, CUTFBAP25011138, CUTFBAP2501201138
Study First Received: January 29, 2013
Last Updated: January 29, 2013
Health Authority: Turkey: Ethics Committee

Additional relevant MeSH terms:
Behcet Syndrome
Cardiovascular Diseases
Eye Diseases
Mouth Diseases
Skin Diseases
Skin Diseases, Vascular
Stomatognathic Diseases
Uveal Diseases
Vascular Diseases
Panuveitis
Uveitis
Uveitis, Anterior
Vasculitis

ClinicalTrials.gov processed this record on November 25, 2014