The Role of Mid-Life Adiposity in Functional Brain Connectivity

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Piero Antuono, MD, Medical College of Wisconsin
ClinicalTrials.gov Identifier:
NCT01777789
First received: January 24, 2013
Last updated: September 19, 2013
Last verified: September 2013
  Purpose

The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's disease.


Condition
Healthy Volunteers

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Role of Mid-Life Adiposity in Functional Brain Connectivity

Resource links provided by NLM:


Further study details as provided by Medical College of Wisconsin:

Primary Outcome Measures:
  • Brain connectivity measured by fMRI [ Time Frame: One visit ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Blood draw


Estimated Enrollment: 60
Study Start Date: December 2012
Estimated Study Completion Date: June 2014
Estimated Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Detailed Description:

Participants will have one visit for:

  • Blood draw
  • Body composition scan
  • Cognitive screen
  • Neurological exam
  • MRI scan

The visit will take approximately 3 hours.

  Eligibility

Ages Eligible for Study:   45 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy volunteers from the community

Criteria

Inclusion Criteria:

  • 45-65 years of age
  • Normal memory
  • Right-handed
  • General good physical health

Exclusion Criteria:

  • History of stroke or neurological disease
  • Seizures or head injury with loss of consciousness within the last five years
  • Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
  • Claustrophobia

More detailed inclusion/exclusion criteria must be met in order to qualify for the study. The study coordinator will determine eligibility.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01777789

Locations
United States, Wisconsin
Medical College of Wisconsin/Froedtert Hospital
Milwaukee, Wisconsin, United States, 53226
Sponsors and Collaborators
Medical College of Wisconsin
Investigators
Principal Investigator: Piero Antuono, MD Medical College of Wisconsin
  More Information

No publications provided

Responsible Party: Piero Antuono, MD, Professor, Medical College of Wisconsin
ClinicalTrials.gov Identifier: NCT01777789     History of Changes
Other Study ID Numbers: PRO16109
Study First Received: January 24, 2013
Last Updated: September 19, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by Medical College of Wisconsin:
Healthy volunteers
fMRI
Dementia
Alzheimer's disease
functional neuroimaging
Memory

ClinicalTrials.gov processed this record on April 17, 2014