Randomized Clinical Trial of Intensive Computer-based Cognitive Remediation in Recent-onset Schizophrenia (TARA)

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2013 by Posit Science Corporation
Sponsor:
Collaborator:
National Institute for Health Research, United Kingdom
Information provided by (Responsible Party):
Posit Science Corporation
ClinicalTrials.gov Identifier:
NCT01773239
First received: January 17, 2013
Last updated: May 13, 2013
Last verified: May 2013
  Purpose

The purpose of this study is to test a new computerized training program as well as to find out whether the computer training might help people who have schizophrenia. The investigators will study the effects of the computer training on how people with schizophrenia think about social interaction and on their social skills. At completion of training, TARA subjects will show improvement on measures of social cognition compared to their baseline performance.


Condition Intervention
Schizophrenia
Behavioral: TARA computer-based exercises

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Randomized Clinical Trial of Intensive Computer-based Cognitive Remediation in Recent-onset Schizophrenia -Targeted Affective Remediation Approach (TARA)

Resource links provided by NLM:


Further study details as provided by Posit Science Corporation:

Primary Outcome Measures:
  • Source Memory Test [ Time Frame: Baseline ] [ Designated as safety issue: No ]
  • Temporal Experience of Pleasure Scale [ Time Frame: Baseline ] [ Designated as safety issue: No ]
  • Quality of Life Scale [ Time Frame: Baseline ] [ Designated as safety issue: No ]
  • Social Functioning Scale [ Time Frame: Baseline ] [ Designated as safety issue: No ]
  • Global Social and Role Functioning Scale [ Time Frame: Baseline ] [ Designated as safety issue: No ]
  • Theories of Intelligence [ Time Frame: Baseline ] [ Designated as safety issue: No ]
  • Faux Pas test [ Time Frame: Baseline ] [ Designated as safety issue: No ]
  • Behavioral Inhibition/Behavioral Activation Scale [ Time Frame: Baseline ] [ Designated as safety issue: No ]
  • Wechsler Test of Adult Reading [ Time Frame: Assessed up to four weeks after training ] [ Designated as safety issue: No ]
  • Penn Facial Memory Test [ Time Frame: Assessed up to four weeks after training ] [ Designated as safety issue: No ]
  • Measure of Insight into Cognition [ Time Frame: Assessed up to four weeks after training ] [ Designated as safety issue: No ]
  • Mayer-Salovey-Caruso Emotional Intellience Test (MSCEIT) [ Time Frame: Assessed up to four weeks after training ] [ Designated as safety issue: No ]

Estimated Enrollment: 16
Study Start Date: May 2012
Estimated Study Completion Date: July 2013
Estimated Primary Completion Date: July 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: TARA computer-based exercises

TARA is a computerized social cognitive (SC) remediation program consisting of a set of specific SC exercises. The program creates a game-like experience where the participant is encouraged to earn points and in-game rewards to further advance in each 'game'. Participants perform tens to hundred of trials over the course of their session, with each trial providing auditory and visual feedback and rewards to indicate if the trial was performed correctly or incorrectly. After each trial, the difficulty of the next trial is updated to ensure that within each session, the participant gets ~85% of trials correct. Summary screens including game metrics (points, levels) and exercise metrics (usage, progress) are shown to the participant at the end of each session.

Participants in the TARA computer-based exercises arm will complete baseline- assessments, 24 hours of TARA computer based-exercises, and repeat post-assessments.

Behavioral: TARA computer-based exercises
Other Names:
  • Targeted Affective Remediation Approach
  • TARA

Detailed Description:

This study employs two computerized programs: TARA (the treatment program), and a set of ordinary computer games (the active control program). Participants will be asked to use their assigned program (treatment or active control) for one hour per session, for four-five sessions per week, over 8-10 weeks (40 total sessions). Several elements of flexibility are allowed in the schedule to accommodate the challenges that people with ASD can face.

  Eligibility

Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • The investigators will study outpatient volunteer subjects who have schizophrenia, schizophreniform disorder or schizoaffective disorder and have experienced their first psychotic episode within the past 5 years, who are clinically stable, and who are between the ages of 18 and 35 years. Approximately 35-40% of the subjects recruited will be female, approximately 50-60% of potential subjects will be Euro-American, 10-20% will be Asian-American, 15-20% Latino, 15-20% African-American. The subject sample will reflect the racial and ethnic diversity of Northern California and the prevalence of schizophrenia across gender in this age period.
  • The investigators will study volunteer subjects at high risk for psychosis who are clinically stable, and who are between the ages of 12-35. Approximately 35-40% of the subjects recruited will be female, approximately 50-60% of potential subjects will be Euro-American, 10-20% will be Asian-American, 15-20% Latino, 15-20% African-American. Our subject sample will reflect the racial and ethnic diversity of the San Francisco Bay Area.
  • The study will have volunteer healthy controls matched by age and gender to our subjects at high risk for psychosis.
  • The study subjects will not have their medications changed by the study researchers. If a subject's personal doctor changes a medication, the change will simply be documented by the study researchers.
  • Investigators will recruit subjects with a clinical diagnosis of schizophrenia, schizophreniform or schizoaffective disorder with first psychotic episode within the last 5 years, good general physical health; age between 12 and 35 years; Is fluent and proficient in the English language; no neurological disorder. In addition, all subjects must have achieved clinical stability, defined as outpatient status for at least 3 months prior to study participation, plus stable doses of psychiatric medications for at least one month prior to study participation using the following operationalized definition: stable low to moderate dose of antipsychotic medication (<1000 mg. chlorpromazine equivalents) for at least 4 weeks prior to study, plus stable doses of all other psychotropic medications (anticholinergics, benzodiazepines) for at least 4 weeks prior to entry. However, subjects are not required to be on medications during participation. Minors must have parental/legal guardian consent to participate. Although investigators request that a family member also participate in the clinical assessments, this is not required for a participant to be eligible.

This study will also recruit subjects who meet criteria for a Prodromal Syndrome as defined on the SIPS:

  • Attenuated Positive Prodromal Syndrome: Ideas of reference, odd beliefs or magical thinking, paranoid ideation, odd thinking and speech, odd behavior and appearance that are at a prodromal level of intensity that is rated at the level of 3-5 on the Scale of Prodromal Symptoms (SOPS). Symptoms must occur at an average frequency of at least once per week in the past month.
  • Brief Intermittent Psychotic Syndrome: Positive symptoms rated at psychotic intensity as a score of 6 on the SOPS that are not disorganizing or dangerous, do not last more than 1 hour per day at an average frequency of four days per week over one month, and have begun in the past three months, currently present at least several minutes a day at a frequency of at least once per month.
  • Genetic Risk and Deterioration Syndrome: Schizotypal personality disorder OR first degree relative with a DSM-IV psychotic disorder, PLUS significant decrease in functioning defined as 30% or greater drop in GAF score during the last month compared to 12 months ago.
  • High Risk Syndromes: Individuals who experience subthreshold psychotic symptoms without restrictions on frequency of onset, functional impairment, or family history of psychosis.
  • Investigators will recruit age and gender matched healthy comparison subjects who do not meet criteria for any Axis I diagnosis on the SCID. They cannot meet prodromal criteria on the Prodromal Questionnaire administered during the screening.
  • All subjects must be in good general physical health; Fluent and proficient in the English language.
  • Minors must have parental/legal guardian consent to participate. Although investigators request that a family member also participate in the clinical assessments, this is not required for a proband to be eligible.
  • Individuals with a diagnosis of schizophrenia do not need to be within the 5 years of onset, as that might have passed while in the first part of the study. Also, they must be at least 18 years of age due to the developmental considerations for the social cognition software of someone who is under the age of 18. The 16 healthy controls also run in this part of the study will be age and gender matched to the individuals with a diagnosis of schizophrenia.

Exclusion Criteria:

  • Recent Onset Schizophrenia Subjects: Investigators will exclude subjects with a history of psychoactive substance abuse in past 6 months determined by DSM-IV criteria from the SCID interview.
  • Prodromal Subjects: Psychotic disorder previously diagnosed as schizophrenia or schizoaffective disorder or psychotic syndrome as defined by the SIPS: Fully psychotic symptoms have occurred at least one hour per day at a minimum average frequency of 4 days per week over one month OR the psychotic symptom is seriously disorganizing or dangerous.
  • Healthy Control Subjects: Criteria is met for any Axis I diagnosis on the SCID. Healthy controls cannot have any first or second degree relative with a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder. Any previous psychiatric hospitalizations will exclude a healthy control from the study.
  • Any subject presenting a significant danger to self or others who requires inpatient treatment will be referred for that treatment and evaluated for study eligibility only after acute care treatment is no longer necessary.
  • Subjects will also be excluded if they have a neurological disorder, or mental retardation (IQ < 70 previously documented, or by intellectual testing, if necessary), or autism.
  • Physical disability that prohibits testing (deafness or blindness).
  • Subjects will be excluded if they currently meet DSM-IV criteria for alcohol/substance dependence or has met criteria within the last 6 months OR prodromal symptoms are present only during use and withdrawal from alcohol/substances OR subject is unable to attend assessments sober.
  • Any contraindications to receiving an MRI scan, including having metal implants or metal fragments in their body.
  • Any history of head injury with loss of consciousness greater than 30 minutes.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01773239

Contacts
Contact: Lindsay K Mayott, B.A. (415)221-4810 ext 3944 Lindsay.mayott@va.gov
Contact: Mor Nahum, Ph.D. (415)269-2425 mor.nahum@brainplasticity.com

Locations
United States, California
Langley Porter Psychiatric Institute, UCSF Recruiting
San Francisco, California, United States, 94143
Contact: Lindsay Mayott, B.A.    415-221-4810 ext 3944    lindsay.mayott@va.gov   
San Francisco Veterans Affairs Medical Center Recruiting
San Francisco, California, United States, 94121
Contact: Lindsay K Mayott, B.A.    415-221-4810 ext 3944    lindsay.mayott@va.gov   
Sponsors and Collaborators
Posit Science Corporation
National Institute for Health Research, United Kingdom
Investigators
Principal Investigator: Sophia Vinogradiv, MD San Francisco Veterans Affairs Medical Center
Principal Investigator: Mor Nahum, Ph.D. Posit Science Corporation
Principal Investigator: Rachel Loewy University of California, San Francisco
  More Information

No publications provided

Responsible Party: Posit Science Corporation
ClinicalTrials.gov Identifier: NCT01773239     History of Changes
Other Study ID Numbers: 1R43MH091793-01A1
Study First Received: January 17, 2013
Last Updated: May 13, 2013
Health Authority: United States: Institutional Review Board
United States: Food and Drug Administration

Keywords provided by Posit Science Corporation:
social cognition
cognitive deficits
prodromal schizophrenia
recent-onset schizophrenia
remediation
computer training
cognitive training exercises

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia and Disorders with Psychotic Features
Mental Disorders

ClinicalTrials.gov processed this record on August 26, 2014