The Effects of Anethesia on Patients Undergoing Surgery for Repair of a Thoracoabdominal Aneurysm.
Alzheimer's disease represents a growing public health problem in developed countries. Although the pathogenesis is not clearly defined, accumulation of extracellular amyloid, neurofibrillary tangles and neuronal loss are the hallmarks of Alzheimer's disease. The effect of anesthetic agents on changes in these proteins in humans is not well characterized, but in-vitro evidence suggests that anesthetic agents can accelerate potential pathogenic mechanisms, such as increasing amyloid formation or rates of apoptosis in cultured cells and increasing amyloid levels in mice. Human data on the effect of anesthetic agents on amyloid and tau proteins is limited to a small series of 11 patients and showed a significant increase in tau levels after exposure to anesthetics. In this study we propose to measure CSF and serum biomarkers in a population of patients with normal CSF dynamics, who are undergoing surgery for repair of a thoracoabdominal aneurysm. We will also obtain preliminary data on whether changes in CSF levels of these proteins are associated with postoperative delirium or cognitive change.
Open Thoracoabdominal Aneurysm Repair
Thoracoabdominal Aneursym Stent
Thoracoabdominal Aneursym Repair With Cardiopulmonary Bypass
|Study Design:||Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
|Official Title:||The Effect of Anesthesia on Potential CSF and Serum Markers of Alzheimer's Disease.|
- Changes in CSF levels of tau and amyloid [ Time Frame: 48 months ] [ Designated as safety issue: No ]
- Delirium and cognitive change [ Time Frame: 48 months ] [ Designated as safety issue: No ]
- Serum inflammatory markers [ Time Frame: 48 months ] [ Designated as safety issue: No ]
|Study Start Date:||May 2012|
|Estimated Study Completion Date:||May 2016|
|Estimated Primary Completion Date:||May 2016 (Final data collection date for primary outcome measure)|
Intravenous anesthetic - patients will be induced with 1-2mg/kg of Propofol and maintained with 25-200 mcg/kg/min of Propofol.
Active Comparator: Isoflurane
standard of care anesthetic - patients will be induced with 1-2 mg/kg of propofol and maintained with 0.5%-1.5% of isoflurane.
|Contact: Charles Brown, MDfirstname.lastname@example.org|
|Contact: Mirinda Anderson White, RNemail@example.com|
|United States, Maryland|
|Johns Hopkins Hospital||Recruiting|
|Baltimore, Maryland, United States, 21287|
|Contact: Charles Brown, MD 410-955-0994 firstname.lastname@example.org|
|Contact: Mirinda Anderson White, RN 410-955-6488 email@example.com|
|Sub-Investigator: Ahbay Moghekar, M.B.B.S|
|Sub-Investigator: James Black, MD|
|Principal Investigator:||Charles Brown, MD||Johns Hopkins University|