Measurement of Retinal Venous Pressure in Chronic Low-oxygen Environment
The hypothesis is that the pressure in the retinal veins increases from chronic lack of oxygen and leads to decreased blood flow. On the basis of high altitude mountaineering this hypothesis should be verified. At the same time the adaptation capacity of the blood circulation should be analyzed, and a relationship to mountain sickness should be found.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Measurement of the Retinal Venous Pressure (RVP) Under Conditions of Chronically Reduced Ambient Pressure and Oxygen Partial Pressure (Field Study)|
- Quantify the changes in the retinal venous pressure (RVP). [ Time Frame: 1-2 months ] [ Designated as safety issue: No ]Quantify the changes in the retinal venous pressure (RVP)
|Study Start Date:||December 2011|
|Estimated Study Completion Date:||December 2013|
|Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
Conduct a field study to describe and quantify the retinal venous pressure (RVP) in healthy volunteers under conditions of controlled chronically reduced ambient pressure and oxygen partial pressure in the mountains. Obtaining indications regarding the adaptation of the retinal vascular system behavior to controlled, long-term hypoxic changes. Comparisons with blood pressure, pulse, oxygen saturation level and the appearance of symptoms of acute mountain sickness are made in order to obtain a better understanding of the development of high altitude illness.
|University of Basel, Dept. of Ophthalmology|
|Basel, Switzerland, 4031|
|Study Director:||Josef Flammer, MD||University of Basel, Dept. of Ophthalmology|