Pilot Study on In-vivo Non-invasive Skin Imaging Using Multiphoton Microscopy

This study is enrolling participants by invitation only.
Information provided by (Responsible Party):
Montana Compton, University of California, Irvine
ClinicalTrials.gov Identifier:
First received: January 15, 2013
Last updated: July 31, 2014
Last verified: July 2014

The researchers wants to use the multiphoton microscopy to non-invasively image in-vivo pigmented and non-pigmented human skin. Currently, there is no standard non-invasive method for skin imaging. Researchers of the Beckman Laser Institute (BLI) have developed many non-invasive imaging modalities for assessment of skin. In this study, a multiphoton tomograph (MPM/MPTflex) will be used for assessment of skin.

Condition Intervention
Skin Lesion
Device: multiphoton microscopy.

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Pilot Study on In-vivo Non-invasive Skin Imaging Using MPM

Further study details as provided by University of California, Irvine:

Primary Outcome Measures:
  • Non-invasive Skin Imaging [ Time Frame: up to 12 months ] [ Designated as safety issue: No ]
    Non-invasive Skin Imaging

Estimated Enrollment: 20
Study Start Date: April 2012
Estimated Study Completion Date: June 2016
Estimated Primary Completion Date: June 2016 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Image parameters for MPM
qualitative image parameters for evaluating the clinical applicability of multiphoton microscopy.
Device: multiphoton microscopy.
multiphoton microscopy.

Detailed Description:

The researchers want to know differences between pigmented and non-pigmented skin areas, such as the presence of melanocytes and the pattern of collagen and elastin networks. Benign and cancerous skin lesions will be imaged and evaluated using the MPM/MPTflex device. The intent is to differentiate benign and cancerous skin lesions without a biopsy, using this non-invasive skin imaging method.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

primary care clinic


Inclusion Criteria:

  • Male or Female age 18 years of age or older
  • Has diagnose with skin pigmented lesion

Exclusion Criteria:

  • Minor and pregnant women
  • Has no pigmented lesion
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01771718

United States, California
Beckman Laser Institute Medical Clinic
Irvine, California, United States, 92612
Sponsors and Collaborators
Montana Compton
Principal Investigator: Kristen Kelly, MD Beckman Laser Institute, UCI
  More Information

No publications provided

Responsible Party: Montana Compton, Research Nurse, University of California, Irvine
ClinicalTrials.gov Identifier: NCT01771718     History of Changes
Other Study ID Numbers: ROI-29410
Study First Received: January 15, 2013
Last Updated: July 31, 2014
Health Authority: United States: Institutional Review Board

ClinicalTrials.gov processed this record on September 14, 2014