Psychophysical Aspects of Maximal Anaerobic Performance
During anaerobic exercise, the metabolic pathway of glycolysis is used in order to produces high-energy compounds adenosine triphosphate (ATP).The level of lactic acid in the blood is a marker to the increased protons concentration and acidosis.nevertheless, the increased level of protons in addition to the release of bradykinin causes pain during the exercise that limited the subject's performance. Therefore, it is assumed that the individual pain sensitivity might determine the subject's performance.
Aims: To investigate the role of the DNIC efficiency in prediction of anaerobic performance in humans (2) to study the role of peripheral pro-nociceptive processing in mediating pain during anaerobic exercise and its contribution to the subjects' performance (3) to assess the function of pain-related psychological factors in anaerobic performance.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Screening
|Official Title:||Psychophysical Aspects of Maximal Anaerobic Performance|
- Pain psychophysics tests [ Time Frame: 1 year ] [ Designated as safety issue: No ]DNIC will be tested using a paradigm of two remote noxious stimuli with one, the 'conditioning stimulus' (immersing the hand in tub containing 8°c water), inhibiting the other, the 'test pain' (pressure pain threshold) in order to assess the EA efficiency (2) heat and pressure pain thresholds, and (3) temporal summation of painful heat and mechanical stimuli that reflect the neuroplasticity of the central nervous system following peripheral noxious stimulation.
- Lactate concentration [ Time Frame: 1 year ] [ Designated as safety issue: No ]Lactate concentration at rest will be measures using a portable lactate analyzer
- The anaerobic performance [ Time Frame: 1 year ] [ Designated as safety issue: No ]will be evaluated during executing of Wingate test
|Study Start Date:||February 2013|
|Estimated Study Completion Date:||April 2013|
|Estimated Primary Completion Date:||February 2013 (Final data collection date for primary outcome measure)|
To the best of our knowledge, no study has investigated the balance between the endogenous anti-nociceptive properties of the individual and the anaerobic-evoke pro-nociceptive activity in determining the maximal performance during anaerobic exercise. Moreover, the interaction between psychological factors and pro- and anti- nociceptive processes that are operated during anaerobic exercise, need to be investigated.
Methods: Forty healthy men and women, between the ages of 18-40 will be involved in the study. Each participant will complete 3 psychological questionnaires regarding their personality traits: Pain Catastrophizing Scale (PCS), State-Trait Anxiety Inventory and Perceived Stress Questionnaire. Pain psychophysics tests will be used for evaluating the individual pain perception, prior and subsequent to the anaerobic exercise: (1) DNIC will be tested using a paradigm of two remote noxious stimuli with one, the 'conditioning stimulus' (immersing the hand in tub containing 8°c water), inhibiting the other, the 'test pain' (pressure pain threshold) in order to assess the endogenous analgesia (EA) efficiency (2) heat and pressure pain thresholds, and (3) temporal summation of painful heat and mechanical stimuli that reflect the neuroplasticity of the central nervous system following peripheral noxious stimulation. In addition, Anaerobic performance will be evaluated during Wingate test,and blood lactate will be measured. Gene related pain ill be tested using saliva samples .
Please refer to this study by its ClinicalTrials.gov identifier: NCT01770288
|Contact: Einat Kodesh, PhDemail@example.com|
|Zinman College for Physical Education and Sport Sciences at the Wingate Institute||Not yet recruiting|
|Netanya, Israel, 42902|
|Contact: Yoav Mekel, PhD|
|Sub-Investigator: Irit Weisman-Fogel, PhD|
|Principal Investigator: Yoav Mekel, PhD|
|Principal Investigator:||Einat Kodesh, PhD||University of Haifa|