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Psychophysical Aspects of Maximal Anaerobic Performance

This study is not yet open for participant recruitment.
Verified January 2013 by Hillel Yaffe Medical Center
Sponsor:
Collaborators:
University of Haifa
Zinman College of Physical Education and Sports Sciences
Information provided by (Responsible Party):
Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier:
NCT01770288
First received: January 6, 2013
Last updated: January 15, 2013
Last verified: January 2013
History of Changes
  Purpose

During anaerobic exercise, the metabolic pathway of glycolysis is used in order to produces high-energy compounds adenosine triphosphate (ATP).The level of lactic acid in the blood is a marker to the increased protons concentration and acidosis.nevertheless, the increased level of protons in addition to the release of bradykinin causes pain during the exercise that limited the subject's performance. Therefore, it is assumed that the individual pain sensitivity might determine the subject's performance.

Aims: To investigate the role of the DNIC efficiency in prediction of anaerobic performance in humans (2) to study the role of peripheral pro-nociceptive processing in mediating pain during anaerobic exercise and its contribution to the subjects' performance (3) to assess the function of pain-related psychological factors in anaerobic performance.


Condition Intervention
Anaerobic Performance
 Other: Anaerobic wingate test

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Screening
Official Title: Psychophysical Aspects of Maximal Anaerobic Performance

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Hillel Yaffe Medical Center:

Primary Outcome Measures:
  • Pain psychophysics tests [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    DNIC will be tested using a paradigm of two remote noxious stimuli with one, the 'conditioning stimulus' (immersing the hand in tub containing 8°c water), inhibiting the other, the 'test pain' (pressure pain threshold) in order to assess the EA efficiency (2) heat and pressure pain thresholds, and (3) temporal summation of painful heat and mechanical stimuli that reflect the neuroplasticity of the central nervous system following peripheral noxious stimulation.


Secondary Outcome Measures:
  • Lactate concentration [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Lactate concentration at rest will be measures using a portable lactate analyzer

  • The anaerobic performance [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    will be evaluated during executing of Wingate test


Estimated Enrollment: 40
Study Start Date: February 2013
Estimated Study Completion Date: April 2013
Estimated Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Anaerobic Performance Other: Anaerobic wingate test

Detailed Description:

To the best of our knowledge, no study has investigated the balance between the endogenous anti-nociceptive properties of the individual and the anaerobic-evoke pro-nociceptive activity in determining the maximal performance during anaerobic exercise. Moreover, the interaction between psychological factors and pro- and anti- nociceptive processes that are operated during anaerobic exercise, need to be investigated.

Methods: Forty healthy men and women, between the ages of 18-40 will be involved in the study. Each participant will complete 3 psychological questionnaires regarding their personality traits: Pain Catastrophizing Scale (PCS), State-Trait Anxiety Inventory and Perceived Stress Questionnaire. Pain psychophysics tests will be used for evaluating the individual pain perception, prior and subsequent to the anaerobic exercise: (1) DNIC will be tested using a paradigm of two remote noxious stimuli with one, the 'conditioning stimulus' (immersing the hand in tub containing 8°c water), inhibiting the other, the 'test pain' (pressure pain threshold) in order to assess the endogenous analgesia (EA) efficiency (2) heat and pressure pain thresholds, and (3) temporal summation of painful heat and mechanical stimuli that reflect the neuroplasticity of the central nervous system following peripheral noxious stimulation. In addition, Anaerobic performance will be evaluated during Wingate test,and blood lactate will be measured. Gene related pain ill be tested using saliva samples .

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

healthy Volunteers

Exclusion Criteria:

pregnancy

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01770288

Contacts
Contact: Einat Kodesh, PhD ekodesh@univ.haifa.ac.il

Locations
Israel
Zinman College for Physical Education and Sport Sciences at the Wingate Institute Not yet recruiting
Netanya, Israel, 42902
Contact: Yoav Mekel, PhD            
Sub-Investigator: Irit Weisman-Fogel, PhD            
Principal Investigator: Yoav Mekel, PhD            
Sponsors and Collaborators
Hillel Yaffe Medical Center
University of Haifa
Zinman College of Physical Education and Sports Sciences
Investigators
Principal Investigator: Einat Kodesh, PhD University of Haifa
  More Information

No publications provided

Responsible Party: Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier: NCT01770288     History of Changes
Other Study ID Numbers: 8-12
Study First Received: January 6, 2013
Last Updated: January 15, 2013
Health Authority: Israel: Ethics Commission

Keywords provided by Hillel Yaffe Medical Center:
Anerobic exercise
Pain
Analgesia
Diffuse Noxious Inhibitory Control (DNIC)
psychological stress

ClinicalTrials.gov processed this record on May 16, 2013