Decoding Chronic Pain With fMRI

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified January 2013 by University of Cambridge
Sponsor:
Information provided by (Responsible Party):
Dr Ben Seymour, University of Cambridge
ClinicalTrials.gov Identifier:
NCT01766973
First received: January 10, 2013
Last updated: NA
Last verified: January 2013
History: No changes posted
  Purpose

Recent evidence suggests that chronic pain is associated with abnormal connectivity between brain regions associated with the processing of pain. We aim to test the diagnostic power of resting state functional magnetic resonance imaging (MRI) to diagnose patients with chronic back pain. Using new methods of image acquisition and analysis we aim to develop a computational method to correctly classify patients and matched control subjects.


Condition
Chronic Back Pain

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Observational Study to Determine Abnormalities in Resting State fMRI in Chronic Back Pain.

Resource links provided by NLM:


Further study details as provided by University of Cambridge:

Primary Outcome Measures:
  • Functional brain connectivity [ Time Frame: 6 months ] [ Designated as safety issue: No ]
    Assessed by fMRI


Estimated Enrollment: 100
Study Start Date: April 2013
Estimated Study Completion Date: April 2018
Estimated Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts
Chronic back pain
Adults, >6months duration
Control
Age and sex matched controls

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Adults with >6 months of mechanical lower back pain, not sue to any major systemic disease

Criteria

Inclusion Criteria:

  • age 18-60
  • pain > 6months
  • right-handed
  • non-smoking
  • mechanical back pain

Exclusion Criteria:

  • significant neurological or psychiatric disease
  • major systemic illness
  • MRI exclusion criteria
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01766973

Contacts
Contact: Ben Seymour, MRCP PhD 01223332600 bjs49@cam.ac.uk

Locations
United Kingdom
Addenbrookes Hospital Not yet recruiting
Cambridge, United Kingdom, CB2 0QQ
Contact: Gopal Kotecha, BSc       gk300@cam.ac.uk   
Principal Investigator: Ben Seymour, MB ChB         
Sponsors and Collaborators
University of Cambridge
Investigators
Principal Investigator: Ben Seymour, MRCP PhD University of Cambridge
  More Information

No publications provided

Responsible Party: Dr Ben Seymour, Wellcome Intermediate Clinical Fellow, University of Cambridge
ClinicalTrials.gov Identifier: NCT01766973     History of Changes
Other Study ID Numbers: CE-U.NA.NFLT.EGDF
Study First Received: January 10, 2013
Last Updated: January 10, 2013
Health Authority: UK: National Health Service

Additional relevant MeSH terms:
Back Pain
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on July 22, 2014