Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Joachim Saur, University Hospital Mannheim
ClinicalTrials.gov Identifier:
NCT01762917
First received: December 21, 2012
Last updated: January 7, 2013
Last verified: January 2013
  Purpose

Non-invasive inert gas rebreathing (IGR) based on the Fick Principle showed promising results in the determination of pulmonary blood flow (PBF). The volume of the rebreathing bag (Vbag) is proposed by the system, however, elderly patients or those suffering from high grade pulmonary diseases might be unable to entirely rebreathe this volume and therefore fail to completely mix the test gases. The aim of our study is to evaluate the effect of adapting Vbag on the reproducibility of IGR measurements in patients with obstruction (group A), restriction (group B) and pulmonary healthy controls (group C).


Condition
Chronic Obstructive Pulmonary Disease
Bronchial Asthma
Restrictive Pulmonary Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Influence of Bag Volume Variation in Inert Gas Rebreathing Pulmonary Blood Flow Measurements on the Reproducibility in Patients With Pulmonary Diseases

Resource links provided by NLM:


Further study details as provided by Universitätsmedizin Mannheim:

Primary Outcome Measures:
  • pulmonary blood flow [ Time Frame: 1 day ] [ Designated as safety issue: No ]
    variation of serial pulmonary blood flow measurements


Enrollment: 45
Study Start Date: September 2007
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
Obstruction
Patients suffering from pulmonary obstruction
Restriction
Patients suffering from pulmonary restriction
Controls
Pulmonary healthy controls

  Eligibility

Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

inpatients and outpatients, internal medicine, university hospital

Criteria

Inclusion Criteria:

  • ability to perform rebreathing maneuver

Exclusion Criteria:

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01762917

Locations
Germany
University Hospital Mannheim
Mannheim, Germany
Sponsors and Collaborators
Universitätsmedizin Mannheim
  More Information

No publications provided

Responsible Party: Joachim Saur, Principal Investigator, University Hospital Mannheim
ClinicalTrials.gov Identifier: NCT01762917     History of Changes
Other Study ID Numbers: IGR_Vbag_MA
Study First Received: December 21, 2012
Last Updated: January 7, 2013
Health Authority: Germany: Ethics Commission

Additional relevant MeSH terms:
Asthma
Lung Diseases
Respiration Disorders
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Bronchial Diseases
Respiratory Tract Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on April 22, 2014