Comparison Between Propofol-remifentanil Total Intravenous Anesthesia and Desflurane-remifentanil Balanced Anesthesia With Regard to Post-anesthetic Functional Recovery Measured With QoR-40

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Yonsei University
ClinicalTrials.gov Identifier:
NCT01760018
First received: December 31, 2012
Last updated: February 17, 2014
Last verified: February 2014
  Purpose

Total intravenous anesthesia (TIVA) and inhalation anesthesia are both widely and safely used, and there are many clinical trials comparing these on various aspects of anesthesia. However, there have not been studies comparing the quality of recovery from the different methods of general anesthesia. In this study, the investigators compare the functional recovery after general anesthesia in TIVA and inhalation anesthesia with QoR-40 questionnaire.


Condition Intervention
Thyroid Operation Under General Anesthesia
Drug: desflurane group
Drug: TIVA group

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)

Resource links provided by NLM:


Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • QoR-40 score [ Time Frame: at 24 hours later after surgery ] [ Designated as safety issue: No ]
    QoR-40 score is going to be measured at preoperative period, 24 hours, and 48 hours later after surgery.


Enrollment: 76
Study Start Date: December 2012
Study Completion Date: January 2013
Primary Completion Date: January 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Desflurane group Drug: desflurane group
anesthesia is maintained with desflurane and remifentanil (Desflurane group)
Active Comparator: TIVA(total intravenous anesthesia) group Drug: TIVA group
anesthesia is maintained with fresofol and remifentanil (TIVA group).

  Eligibility

Ages Eligible for Study:   20 Years to 65 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • patients who are undergoing thyroid operation belong to ASA class 1 or 2

Exclusion Criteria:

  • patients who are belongs to ASA class 3 or more,
  • patients who have underlying complicated cardiovascular or psychological disease.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01760018

Locations
Korea, Republic of
Severance Hospital
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University
  More Information

Publications:
Responsible Party: Yonsei University
ClinicalTrials.gov Identifier: NCT01760018     History of Changes
Other Study ID Numbers: 4-2012-0748
Study First Received: December 31, 2012
Last Updated: February 17, 2014
Health Authority: South Korea: Institutional Review Board

Keywords provided by Yonsei University:
desflurane, total intravenous anesthesia, QoR-40

Additional relevant MeSH terms:
Anesthetics
Remifentanil
Desflurane
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Analgesics, Opioid
Narcotics
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Hypnotics and Sedatives
Anesthetics, Intravenous
Anesthetics, General
Anesthetics, Inhalation

ClinicalTrials.gov processed this record on September 16, 2014