Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 (HAMIL28B)
Only 5 to 10% of patients infected with HTLV-1 develop a disease related to infection. The two most serious diseases are adult T-cell leukemia (ATL) and Tropical spastic paraparesis /HTLV-I-associated myelopathy (TSP / HAM). Factors influencing the development of TSP / HAM in the individual HTLV-1 are not yet completely understood. Patients TSP / HAM have a HTLV-1 proviral load (amount of virus) that is 6-10 times higher than seropositive asymptomatic.
Various studies have shown that the development of TSP / HAM in the subject HTLV-1 and its rapid evolution is partly attributed to the failure of the immune system that regulates viral replication and expression.
It has recently been shown that different versions of Single Nucleotide (human leukocyte antigen) rs12979860, located upstream of the gene for Interleukin 28B (IL28B), influenced the severity of infection with hepatitis C and effectiveness of treatment.
By analogy with hepatitis C, a Spanish (Treviño et al., 2012) examined this SNP(single nucleotide polymorphism) in 12 patients TSP / HAM and 29 asymptomatic HIV-positive. CT or TT genotype was statistically more frequent in the group TSP / HAM than in asymptomatic patients (80% versus 20%) and was associated with HTLV-1 proviral load higher.
We propose a broader group of patients in our population and Afro-Caribbean, to confirm the results of the latter study was conducted in a predominantly Latin American population.
|Study Design:||Observational Model: Case Control
Time Perspective: Retrospective
|Official Title:||Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1|
- Presence of CT or TT allele for each participant [ Time Frame: 30 days ] [ Designated as safety issue: No ]
The participants will be followed until the end of the study ( with an expected average of 30 days after the inclusion).
Explenations : each participant will have a blood sample who will be performed at the recruitement day (for génetics analysis) . After this first visit (recuitement visit) , each participant will have to perform an appointement with the ophtalmologic département ( recuperate datas about the presence or not of an uveitis and a keratoconjunctivitis)
|Study Start Date:||February 2013|
|Estimated Study Completion Date:||August 2013|
|Estimated Primary Completion Date:||February 2013 (Final data collection date for primary outcome measure)|
HTLV-1 infected patients
HAM/TSP patients and HTLV-1 Asymtomatic patients
|Contact: Janick Jean-Marie, Master||(0)596592697 ext email@example.com|
|University Hospital of Fort de France||Not yet recruiting|
|Fort de France, Martinique, 97261|
|Contact: Stephane Olindo, MD (0)596 55 22 61 ext 596 firstname.lastname@example.org|
|Principal Investigator: Stephane Olindo, MD|
|French Blood Establishement||Not yet recruiting|
|Fort-de-France, Martinique, 97264|
|Contact: Pascale RICHARD, MD (0)596 75 79 15 ext 596 email@example.com|
|Principal Investigator: Pascale Richard, MD|
|Principal Investigator:||Stephane Olindo, MD||University Hospital of Fort de France|