The Genetics Behind Vitamin D Status (VitDgen)
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Purpose
The overall purpose of the study is to investigate whether there is a relationship between 26 different single nucleotide polymorphisms (SNPs) in the vitamin D pathway, ultraviolet B (UV-B) irradiation of the skin and vitamin D status.
The hypothesis is that vitamin D status are influated by different genetic genotypes in the vitamin D pathway.
| Condition | Intervention |
|---|---|
|
Vitamin D Deficiency |
Genetic: VitDgen |
| Study Type: | Interventional |
| Study Design: | Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Basic Science |
| Official Title: | The Genetics Behind Vitamin D Status (VitDgen) |
- serum 25-hydroxyvitamin D [ Time Frame: 10 days ] [ Designated as safety issue: No ]Measures the vitamin D status i serum at baseline and at the end of the project
- Skintest [ Time Frame: 10 days ] [ Designated as safety issue: No ]Optimize scientific; measures pigmentation and redness of the skin. Are measured at baseline and at end of project
| Estimated Enrollment: | 80 |
| Study Start Date: | November 2012 |
| Estimated Study Completion Date: | March 2013 |
| Estimated Primary Completion Date: | March 2013 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: UV-B irraditation
VitDgen
|
Genetic: VitDgen |
Detailed Description:
In this study approximately 80 participants (over 18 years) are included. All the participants has previously participated in the VitmaD intervention study (NCT01184716) .
Participants will in total receive 4 times UV-B irradiation (3 SED) with two day apart each time, to stimulate vitamin D production in the skin. The participants skintype will be measured. The study starts in January 2013 and runs to the end of Marts 2013. During this winter period, it is in Denmark not possible to produce vitamin D in the skin through sunlight exposure.
Eligibility| Ages Eligible for Study: | 18 Years to 60 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Health participants over 18 years, that previously participated in VitmaD intervention study
Exclusion Criteria:
- skindiseases
- intake of medicin that causes photosensitive skin
- pregnant or nursing
- sun vacation 3 month before the intervention
- intake of vitamin D supplement 3 month before the intervention
Contacts and Locations| Contact: Ioanna Nissen, PhD student | 004535887062 | ioni@food.dtu.dk |
| Contact: Lone Rasmussen, M.Sc., Ph.D. | 004535887427 | lbra@food.dtu.dk |
| Denmark | |
| Bispebjerg Hospital | Recruiting |
| Bispebjerg, Copenhagen, Denmark, 2400 | |
| Contact: Hans Wulf, Professor 004535313155 Hans.Christian.Olsen.Wulf@regionh.dk | |
| Contact: Ioanna Nissen, Phd stud 004535887062 ioni@food.dtu.dk | |
| Principal Investigator: Ioanna Nissen, Phd Stud | |
| DTU / National Food Institute | Completed |
| Morkhoj, Søborg, Denmark, 2860 | |
| Principal Investigator: | Lone Rasmussen, M.Sc., Ph.D. | DTU, Denmark |
More Information
No publications provided
| Responsible Party: | Lone Banke Rasmussen, M.Sc., Ph.D., Technical University of Denmark |
| ClinicalTrials.gov Identifier: | NCT01741233 History of Changes |
| Other Study ID Numbers: | H-4-2012-071 |
| Study First Received: | November 30, 2012 |
| Last Updated: | December 5, 2012 |
| Health Authority: | Denmark: Ethics Committee |
Keywords provided by Technical University of Denmark:
|
SNPs vitamin D Vitamin D status UVB irradiation genetics |
Additional relevant MeSH terms:
|
Vitamin D Deficiency Avitaminosis Deficiency Diseases Malnutrition Nutrition Disorders Vitamin D Ergocalciferols |
Vitamins Bone Density Conservation Agents Physiological Effects of Drugs Pharmacologic Actions Micronutrients Growth Substances |
ClinicalTrials.gov processed this record on May 19, 2013