The Genetics Behind Vitamin D Status (VitDgen)
The overall purpose of the study is to investigate whether there is a relationship between 26 different single nucleotide polymorphisms (SNPs) in the vitamin D pathway, ultraviolet B (UV-B) irradiation of the skin and vitamin D status.
The hypothesis is that vitamin D status are influated by different genetic genotypes in the vitamin D pathway.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||The Genetics Behind Vitamin D Status (VitDgen)|
- serum 25-hydroxyvitamin D [ Time Frame: 10 days ] [ Designated as safety issue: No ]Measures the vitamin D status i serum at baseline and at the end of the project
- Skintest [ Time Frame: 10 days ] [ Designated as safety issue: No ]Optimize scientific; measures pigmentation and redness of the skin. Are measured at baseline and at end of project
|Study Start Date:||November 2012|
|Study Completion Date:||March 2013|
|Primary Completion Date:||March 2013 (Final data collection date for primary outcome measure)|
In this study approximately 80 participants (over 18 years) are included. All the participants has previously participated in the VitmaD intervention study (NCT01184716) .
Participants will in total receive 4 times UV-B irradiation (3 SED) with two day apart each time, to stimulate vitamin D production in the skin. The participants skintype will be measured. The study starts in January 2013 and runs to the end of Marts 2013. During this winter period, it is in Denmark not possible to produce vitamin D in the skin through sunlight exposure.
|Bispebjerg, Copenhagen, Denmark, 2400|
|DTU / National Food Institute|
|Morkhoj, Søborg, Denmark, 2860|
|Principal Investigator:||Lone Rasmussen, M.Sc., Ph.D.||DTU, Denmark|