Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis
The investigators examined the hypothesis that serum lactate is raised in early necrotizing fasciitis to a much greater extent than in other differential diagnoses, such as severe cellulitis, and therefore provides a diagnostic indicator.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Raised Serum Lactate as a Marker of Necrotizing Fasciitis; a Consecutive Prospective Review.|
- Serum lactate level [ Time Frame: At referral to the Plastic Surgery Team ] [ Designated as safety issue: No ]Serum lactate level at initial referral to the plastic surgery team, as measured by arterial blood gas analysis (calibrated point-of-care testing). Levels compared between the group with confirmed histological necrosis at initial surgical debridement, versus those with no evidence of necrosis (a composite of those who did not undergo surgery as they were judged not to have necrotizing fasciitis, and those who did undergo surgery, but whose histology did not show tissue necrosis).
|Study Start Date:||September 2000|
|Study Completion Date:||September 2010|
|Primary Completion Date:||September 2010 (Final data collection date for primary outcome measure)|
Necrotizing fasciitis proven
Histological evidence of necrotizing fasciitis at initial surgical debridement
Not necrotizing fasciitis
A composite of those with no histological tissue necrosis at initial surgical debridement, and those clinically judged not to be a necrotizing infection who therefore did not undergo surgery.
A prospective comparison of serum lactate levels at referral to the Plastic Surgery team to the 'gold standard' test of histology at initial surgical debridement, looking at 53 consecutive patients referred with suspected necrotizing fasciitis to a single surgeon at one institution between 2000 and 2010.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01739959
|Wexham Park Hospital|
|Slough, London, United Kingdom, SL2 4HL|
|Principal Investigator:||George Murphy, MRCS||Wexham Park Hospital|