On-treatment PLAtelet Reactivity-guided Therapy Modification FOR ST-segment Elevation Myocardial Infarction (PLATFORM)

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified November 2012 by Clinical Centre of Serbia
Sponsor:
Information provided by (Responsible Party):
Igor Mrdovic, Clinical Centre of Serbia
ClinicalTrials.gov Identifier:
NCT01739556
First received: November 22, 2012
Last updated: November 30, 2012
Last verified: November 2012
  Purpose

Adequate platelet inhibition with dual antiplatelet therapy is a key therapeutic goal after primary percutaneous coronary intervention (PPCI), aimed at protecting against stent thrombosis and increased mortality. Recent aggregometric assays have shown that up to one third of acute coronary syndrome patients treated with clopidogrel have incomplete inhibition of adenosine diphosphate(ADP)-induced platelet aggregation while the number of patients treated with aspirin who have incomplete inhibition of thromboxane A2-induced platelet aggregation (ASPI)is much lower. High on-treatment platelet reactivity (HTPR) has been associated with an increased rate of ischemic events after PCI. However, recent large trials did not show a clinical benefit of TPR-guided therapy modification in acute coronary syndrome patients treated by PCI.

On-treatment PLAtelet reactivity-guided Therapy modification FOR ST-segment elevation Myocardial infarction (PLATFORM) is an investigator-initiated, prospective, randomized, parallel-group, controlled clinical trial designed to test the hypothesis that antiplatelet therapy modification is superior to standard antiplatelet regimen among intermediate to high-risk STEMI patients undergoing PPCI. The safety hypothesis is that compared with control arm, interventional study arm will have similar rates of non-coronary artery bypass graft surgery-related bleeding. Approximately 632 ST-elevation myocardial infarction (STEMI) patients with intermediate to high-risk (RISK-PCI score >3) clinical features undergoing PPCI will be randomly allocated to treatment modification or standard treatment. Low responders to aspirin will receive 200 mg aspirin for 30 days. Low responders to clopidogrel will receive 180 mg ticagrelor for 1 year. Patients will be followed up to 1 year after PPCI.


Condition Intervention Phase
Acute ST-elevation Myocardial Infarction
Drug: Antiplatelet Regimen Modification (aspirin or ticagrelor)
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: On-treatment PLAtelet Reactivity-guided Therapy Modification FOR ST-segment Elevation Myocardial Infarction (PLATFORM)

Resource links provided by NLM:


Further study details as provided by Clinical Centre of Serbia:

Primary Outcome Measures:
  • MACE [ Time Frame: up to 1 year ] [ Designated as safety issue: No ]
    The PLATFORM specified primary efficacy end point is the time to first occurrence of any component of the composite MACE (comprising total death, nonfatal infarction, nonfatal stroke and immediate target vessel revascularization).


Secondary Outcome Measures:
  • Total death [ Time Frame: up to 1 year ] [ Designated as safety issue: No ]
    total mortality rate

  • Major bleeding [ Time Frame: up to 1 year ] [ Designated as safety issue: Yes ]
    TIMI major bleeding unrelated to coronary artery bypass graft surgery

  • Total bleeding [ Time Frame: up to 1 year ] [ Designated as safety issue: Yes ]
    all bleeding events

  • Reinfarction [ Time Frame: up to 1 year ] [ Designated as safety issue: No ]
    nonfatal myocardial infarction

  • Stroke [ Time Frame: up to 1 year ] [ Designated as safety issue: No ]
    nonfatal cerebrovascular insult

  • Revascularisation [ Time Frame: up to 1 year ] [ Designated as safety issue: No ]
    ischemia-driven target vessel revascularization

  • Transfusion [ Time Frame: up to 1 year ] [ Designated as safety issue: Yes ]
    need for bood transfusion


Other Outcome Measures:
  • Stent thrombosis [ Time Frame: up to 1 year ] [ Designated as safety issue: No ]
    definite stent thrombosis


Estimated Enrollment: 632
Study Start Date: June 2013
Estimated Study Completion Date: October 2016
Estimated Primary Completion Date: June 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Intervention Arm
Antiplatelet regimen modification will be guided by assessment of the on-treatment platelet reactivity. Low responders to aspirin will receive 200 mg aspirin for 30 days. Low responders to clopidogrel will receive 180 mg ticagrelor for 1 year.
Drug: Antiplatelet Regimen Modification (aspirin or ticagrelor)
No Intervention: Standard Treatment
Patients enrolled in the Standard Treatment arm will receive standard antiplatelet regimen including 100 mg aspirin and 75 mg clopidogrel without assessment of on-treatment platelet reactivity.

Detailed Description:

On-treatment PLAtelet reactivity-guided Therapy modification FOR ST-segment elevation Myocardial infarction (PLATFORM) is an investigator-initiated, prospective, open-label, randomized, parallel-group, actively controlled single-centre clinical trial. The research protocol has been approved by the Ethics Committee of the Clinical Centre of Serbia. All participants will have to provide their informed consent in writing. The trial design will ensure that all participants abide by good clinical practice and the ethical principles of the Declaration of Helsinki II. Patients will be randomly allocated to antiplatelet regimen modification (ARM, interventional arm) or standard treatment (control arm) using a computer-generated 1:1 simple randomization scheme. TPR will be assessed in patients enrolled in the intervention arm of the trial. Low responders to aspirin will receive 200 mg aspirin for 30 days. Low responders to clopidogrel will receive 180 mg ticagrelor for 1 year. Patients enrolled in the control arm will receive standard antiplatelet regimen including 100 mg aspirin and 75 mg clopidogrel without assessment of TPR. The treating physicians will not be blinded to the intervention since an open design will make it possible for investigators to perform necessary adjustments of the antiplatelet regimen in accordance with TPR status. To minimize any possible bias inherent in the open design, endpoints will be evaluated by a blinded endpoint committee. Enrollment will start in June 2013. Recruitment will continue until 632 patients have been randomized. The end of the recruitment period is planned for June 2015. The trial will continue until all available survivors have been followed for at least 1 year.

Aspirin 300 mg and clopidogrel 600 mg loading doses will be administered as early as possible before PPCI. Primary PCI will be performed via femoral or radial approach, using standard 6 French-7 French guiding catheters. The Thrombolysis in Myocardial Infarction (TIMI) blood flow will be measured by two experienced observers blinded to identity and the order of angiograms. Any disagreement will be resolved by a third observer. Unfractionated heparin will be started as 100 IU/kg bolus (60 IU/kg if glycoprotein (GP)IIb/IIIa receptor inhibitor was used); the 12 IU/kg/h infusion will follow if clinically indicated. Proton-pump inhibitor pantoprazole or H2-blocker ranitidine will be given to selected patients at risk for gastrointestinal hemorrhage. GP IIb/IIIa receptor inhibitor tirofiban will be administered during the procedure in patients with evidence of high intracoronary thrombus burden according to the European Society of Cardiology guidelines.

Multiple electrode aggregometry will be performed using the impedance aggregometer and under the monitoring of an official representative of the manufacturer (Multiplate analyzer, Verum-Diagnostics, Munich, Germany). TPR results will be evaluated by 2 investigators who will be blinded to patient's identity and treatment. Whole blood will be sampled 24 hours after the loading dose. In patients who received IIb/IIIa inhibitor tirofiban blood samples will be obtained at least 24 hours after the completion of tirofiban infusion. On-treatment platelet reactivity (TPA) above 50%, compared to the basal value estimated by TRAP test, will be linked with low responsiveness.

Patients will be followed-up after discharge from hospital for net adverse events up to 1 year after enrolment by scheduled telephone interviews and outpatient visits. Interviewers will be blinded to the randomization scheme and to the results of platelet aggregation. An independent Clinical Event Committee, composed of 3 cardiologists and 1 neurologist and blinded with respect to randomization allocation will review and adjudicate the occurrence of each suspected clinical end point. Interim analyses of efficacy and futility, using O'Brian-Fleming guidelines for group sequential design, are planned when one fourth, one half and three fourths of the maximum number of the 632 patients had been followed-up for 30 days. Interim analyses and all safety data will be reviewed by an independent Data Safety and Monitoring Committee, composed of a chairman, a statistician, and 2 physician members.

  Eligibility

Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • 18 years and older, willing consent, undergoing primary PCI for STEMI, within 12 hours of the onset of symptoms, stent implanted successfully, RISK-PCI score for 30-day MACE >3, alive 24 hours after loading doses, ability to comply with study protocol, negative pregnancy test for women of childbearing potential before enrollment, agree to use a reliable method of birth control during the study

Exclusion Criteria:

  • Pre-procedural
  • history of hemorrhagic stroke
  • ischemic stroke within 30 days of randomization
  • evidence of active abnormal bleeding within 3 months of randomization
  • high risk for bleeding on long-term antiplatelet therapy
  • current therapy with coumadin anticoagulant
  • Pregnancy or nursing
  • current enrollment in another investigational study Procedural
  • balloon angioplasty without stent placement
  • unsuccessful PPCI (post-procedural TIMI flow 0) Post-procedural
  • active bleeding
  • hemoglobin <10 g/dL or drop in hemoglobin by ≥3 g/dL
  • platelet count <100 000 x 10-9/L.
  • TRAP value <500 aggregation units
  • indication for permanent anticoagulant therapy
  • need for urgent surgical revascularization
  • vascular pseudoaneurysm
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01739556

Contacts
Contact: Igor Mrdovic, Ph.D +381113662364 igormrd@gmail.com

Locations
Serbia
Clinical Centre of Serbia, Emergency Hospital Not yet recruiting
Belgrade, Serbia, 11000
Sub-Investigator: Lidija Savic, Ph.D         
Sub-Investigator: Gordana Krljanac, MD         
Sub-Investigator: Milika Asanin, Ph.D         
Sub-Investigator: Nemanja Djuricic, MD         
Sub-Investigator: Sanja Stankovic, Ph.D         
Sub-Investigator: Jelena Marinkovic, Ph.D         
Sponsors and Collaborators
Clinical Centre of Serbia
Investigators
Principal Investigator: Igor Mrdovic, Ph.D Clinical Centre of Sebria
Study Director: Jovan Perunicic, Ph.D Clinical Centre of Serbia
  More Information

No publications provided by Clinical Centre of Serbia

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Igor Mrdovic, Associate Professor, Clinical Centre of Serbia
ClinicalTrials.gov Identifier: NCT01739556     History of Changes
Other Study ID Numbers: CCS-553-12
Study First Received: November 22, 2012
Last Updated: November 30, 2012
Health Authority: Serbia: Ethics Committee

Keywords provided by Clinical Centre of Serbia:
antiplatelet therapy
primary PCI
modification

Additional relevant MeSH terms:
Infarction
Myocardial Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Aspirin
Ticagrelor
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Pharmacologic Actions
Anti-Inflammatory Agents
Therapeutic Uses
Antirheumatic Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Cardiovascular Agents
Hematologic Agents
Platelet Aggregation Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Antipyretics

ClinicalTrials.gov processed this record on September 18, 2014