Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections

This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2012 by Universitaire Ziekenhuizen Leuven
Sponsor:
Information provided by (Responsible Party):
Peter Verhamme, Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov Identifier:
NCT01731483
First received: November 15, 2012
Last updated: November 20, 2012
Last verified: November 2012
  Purpose

the aim of this study is to investigate the role of staphylokinase, streptokinase and MMP activation in invasive staphylococcal and streptococcal infections.


Condition
Coagulation Fibrinolysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections.

Resource links provided by NLM:


Further study details as provided by Universitaire Ziekenhuizen Leuven:

Biospecimen Retention:   Samples Without DNA

tissue specimens from endocarditis lesions and necrotizing fasciitis


Estimated Enrollment: 130
Study Start Date: July 2012
Estimated Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Material will be collected from all patients that undergo surgical treatment for invasive streptococcal or staphylococcal infections, including acute infective endocarditis and necrotizing fasciitis, from the UZ Leuven University Hospital

Criteria

Inclusion Criteria:

  • all patients that undergo surgical treatment for invasive streptococcal or staphylococcal infections, including acute infective endocarditis and necrotizing fasciitis, from the UZ Leuven University Hospital

Exclusion Criteria:

  • none
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01731483

Locations
Belgium
UZ Leuven University Hospital Recruiting
Leuven, Belgium, 3000
Contact: Peter Verhamme, Prof.    +32 16 34 34 91      
Principal Investigator: Peter Verhamme, Prof.         
Sponsors and Collaborators
Universitaire Ziekenhuizen Leuven
  More Information

No publications provided

Responsible Party: Peter Verhamme, Prof. Verhamme, Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov Identifier: NCT01731483     History of Changes
Other Study ID Numbers: M-1
Study First Received: November 15, 2012
Last Updated: November 20, 2012
Health Authority: Belgium: Ethics Committee

Keywords provided by Universitaire Ziekenhuizen Leuven:
virulence factors

Additional relevant MeSH terms:
Streptococcal Infections
Gram-Positive Bacterial Infections
Bacterial Infections

ClinicalTrials.gov processed this record on October 19, 2014